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Literature summary extracted from

  • de Souza Junior, D.A.; Santana, A.C.; da Silva, E.Z.; Oliver, C.; Jamur, M.C.
    The role of mast cell specific chymases and tryptases in tumor angiogenesis (2015), BioMed Res. Int., 2015, 142359 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.39 chymostatin
-
 Homo sapiens
3.4.21.39 chymostatin
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.39 angiotensin I + H2O Mus musculus
-
 angiotensin II + His-Leu
-
 ?
3.4.21.39 angiotensin I + H2O Homo sapiens
-
 angiotensin II + His-Leu
-
 ?
3.4.21.39 big-endothelin-1 + H2O Mus musculus
-
 ?
-
 ?
3.4.21.39 big-endothelin-1 + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.39 big-endothelin-2 + H2O Mus musculus
-
 ?
-
 ?
3.4.21.39 big-endothelin-2 + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.39 pro-matrix metalloproteinase-9 + H2O Mus musculus
-
 matrix metalloproteinase-9 + ?
-
 ?
3.4.21.39 pro-matrix metalloproteinase-9 + H2O Homo sapiens
-
 matrix metalloproteinase-9 + ?
-
 ?
3.4.21.39 procollagen + H2O Mus musculus
-
 collagen + ?
-
 ?
3.4.21.39 procollagen + H2O Homo sapiens
-
 collagen + ?
-
 ?
3.4.21.39 thrombin + H2O Mus musculus
-
 ?
-
 ?
3.4.21.39 thrombin + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.39 tissue inhibitor of metalloproteinase-1 + H2O Mus musculus
-
 ?
-
 ?
3.4.21.39 tissue inhibitor of metalloproteinase-1 + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.39 transforming growth factor-beta1 + H2O Mus musculus
-
 ?
-
 ?
3.4.21.39 transforming growth factor-beta1 + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.59 fibrinogen + H2O Mus musculus
-
 fibrin + ?
-
 ?
3.4.21.59 fibrinogen + H2O Homo sapiens
-
 fibrin + ?
-
 ?
3.4.21.59 plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?
3.4.21.59 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?
3.4.21.59 protease activated receptor-2 + H2O Mus musculus
-
 ?
-
 ?
3.4.21.59 protease activated receptor-2 + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.39 Homo sapiens
-
-
-
3.4.21.39 Mus musculus
-
-
-
3.4.21.59 Homo sapiens
-
-
-
3.4.21.59 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.39 mast cell
-
 Mus musculus
-
3.4.21.39 mast cell
-
 Homo sapiens
-
3.4.21.59 mast cell
-
 Mus musculus
-
3.4.21.59 mast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.39 angiotensin I + H2O
-
 Mus musculus angiotensin II + His-Leu
-
 ?
3.4.21.39 angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
3.4.21.39 big-endothelin-1 + H2O
-
 Mus musculus ?
-
 ?
3.4.21.39 big-endothelin-1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 big-endothelin-2 + H2O
-
 Mus musculus ?
-
 ?
3.4.21.39 big-endothelin-2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 pro-matrix metalloproteinase-9 + H2O
-
 Mus musculus matrix metalloproteinase-9 + ?
-
 ?
3.4.21.39 pro-matrix metalloproteinase-9 + H2O
-
 Homo sapiens matrix metalloproteinase-9 + ?
-
 ?
3.4.21.39 procollagen + H2O
-
 Mus musculus collagen + ?
-
 ?
3.4.21.39 procollagen + H2O
-
 Homo sapiens collagen + ?
-
 ?
3.4.21.39 thrombin + H2O
-
 Mus musculus ?
-
 ?
3.4.21.39 thrombin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 tissue inhibitor of metalloproteinase-1 + H2O
-
 Mus musculus ?
-
 ?
3.4.21.39 tissue inhibitor of metalloproteinase-1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 transforming growth factor-beta1 + H2O
-
 Mus musculus ?
-
 ?
3.4.21.39 transforming growth factor-beta1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.59 fibrinogen + H2O
-
 Mus musculus fibrin + ?
-
 ?
3.4.21.59 fibrinogen + H2O
-
 Homo sapiens fibrin + ?
-
 ?
3.4.21.59 additional information the enzyme cleaves preferentially after Lys/Arg residues Mus musculus ?
-
 ?
3.4.21.59 additional information the enzyme cleaves preferentially after Lys/Arg residues Homo sapiens ?
-
 ?
3.4.21.59 plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?
3.4.21.59 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
3.4.21.59 protease activated receptor-2 + H2O
-
 Mus musculus ?
-
 ?
3.4.21.59 protease activated receptor-2 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.39 monomer
-
 Mus musculus
3.4.21.39 monomer
-
 Homo sapiens
3.4.21.59 tetramer
-
 Mus musculus
3.4.21.59 tetramer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.39 CMA1
-
 Homo sapiens
3.4.21.39 mast cell specific chymase
-
 Mus musculus
3.4.21.39 mast cell specific chymase
-
 Homo sapiens
3.4.21.39 MCP-1 isoform Mus musculus
3.4.21.39 MCP-4 isoform Mus musculus
3.4.21.59 alpha-tryptase major circulating isoform Homo sapiens
3.4.21.59 beta-tryptase major type stored in secretory granules Homo sapiens
3.4.21.59 mast cell specific tryptase
-
 Mus musculus
3.4.21.59 mast cell specific tryptase
-
 Homo sapiens
3.4.21.59 MCP-6
-
 Mus musculus
3.4.21.59 MCP-7
-
 Mus musculus
3.4.21.59 Mcpt6
-
 Mus musculus
3.4.21.59 TPSAB1
-
 Mus musculus
3.4.21.59 TPSAB1
-
 Homo sapiens
3.4.21.59 TPSB2
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.59 Mus musculus tryptase (MCP-6 and MCP-7) expression and activity are increased during progression of skin tumors in mice up

General Information

EC Number General Information Comment Organism
3.4.21.39 physiological function the enzyme plays a role in angiogenesis of tumors Mus musculus
3.4.21.39 physiological function the enzyme plays a role in angiogenesis of tumors Homo sapiens
3.4.21.59 physiological function tryptase interacts directly with endothelial cells to induce angiogenesis Homo sapiens
3.4.21.59 physiological function tryptase interacts directly with endothelial cells to induce angiogenesis. Tryptase affects angiogenesis in myocardial microvascular endothelial cells via angiopoietin-2/Tie-2 Mus musculus