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Literature summary extracted from

  • Banu, S.K.; Stanley, J.A.; Sivakumar, K.K.; Arosh, J.A.; Barhoumi, R.; Burghardt, R.C.
    Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats (2015), Biol. Reprod., 92, 67 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.9 Cr6+ CrVI, a heavy metal endocrine-disrupting chemical industrially widely used, gestational exposure to CrVI increases germ cell/oocyte apoptosis and advance germ cell nest (GCN) breakdown. CrVI increases X-prolyl aminopeptidase (Xpnpep) 2 (a marker for premature ovarian failure in humans) during germ cell nest (GCN) breakdown, it decreases Xpnpep2 during postnatal follicle development, and increases colocalization of Xpnpep2 with collagens Col3 and Col4. Phenotype, overview Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.9 Rattus norvegicus Q99MA2
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3.4.11.9 Rattus norvegicus Sprague Dawley Q99MA2
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.9 ovary the enzyme colocalizes with collagens Col3 and Col4 in fetal ovaries around the germ cells, GCN, and along the ovigerous cords Rattus norvegicus
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Synonyms

EC Number Synonyms Comment Organism
3.4.11.9 X-prolyl aminopeptidase 2
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 Rattus norvegicus
3.4.11.9 XPNPEP2
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 Rattus norvegicus