EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.355 | expressed in Mus musculus | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Homo sapiens | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.355 | Homo sapiens | Q96KQ7 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.355 | Hep-G2 cell | - |
Homo sapiens | - |
2.1.1.355 | hepatocyte | - |
Homo sapiens | - |
2.1.1.355 | liver | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | overall reaction | Homo sapiens | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.355 | EHMT2 | - |
Homo sapiens |
2.1.1.355 | G9a | - |
Homo sapiens |
2.1.1.355 | histone methyltransferase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.355 | malfunction | in cultured hepatic cells, enzyme knockdown results in downregulation of insulin receptor, p-AKT and p-GSK3beta | Homo sapiens |
2.1.1.355 | physiological function | the enzyme modulates hepatic insulin signaling via regulating HMGA1 (high mobility group AT-hook 1, a key regulator responsible for the transcription of insulin receptor gene). In cultured hepatic cells, enzyme upregulation prevents the palmitic acid- or glucosamine-induced insulin resistance by preserving the normal level of insulin receptor and integrity of insulin signaling. | Homo sapiens |