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Literature summary extracted from

  • Hans, M.; Bill, E.; Cirpus, I.; Pierik, A.; Hetzel, M.; Alber, D.; Buckel, W.
    Adenosine triphosphate-induced electron transfer in 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans (2002), Biochemistry, 41, 5873-5882 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.9 Acidaminococcus fermentans P11568
-
-
5.6.1.9 Acidaminococcus fermentans DSM 20731 P11568
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.9 2 ATP + a reduced flavodoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O
-
 Acidaminococcus fermentans 2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyglutaryl-CoA dehydratase
-
 ?
5.6.1.9 2 ATP + a reduced flavodoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O
-
 Acidaminococcus fermentans DSM 20731 2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyglutaryl-CoA dehydratase
-
 ?
5.6.1.9 additional information oxidized component A exhibits ATPase activity of 6 s-1, which is completely abolished upon reduction by one electron. In the presence of ATP, one electron is transferred from flavodoxin hydroquinone via the [4Fe-4S]1+/2+ cluster of component A to Mo(VI) of 2-hydroxyglutaryl-CoA dehydratase, which is thereby reduced to Mo(V) Acidaminococcus fermentans ?
-
 ?
5.6.1.9 additional information oxidized component A exhibits ATPase activity of 6 s-1, which is completely abolished upon reduction by one electron. In the presence of ATP, one electron is transferred from flavodoxin hydroquinone via the [4Fe-4S]1+/2+ cluster of component A to Mo(VI) of 2-hydroxyglutaryl-CoA dehydratase, which is thereby reduced to Mo(V) Acidaminococcus fermentans DSM 20731 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.9 2-hydroxyglutaryl-CoA dehydratase component A
-
 Acidaminococcus fermentans
5.6.1.9 HgdC
-
 Acidaminococcus fermentans

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.1.9 4Fe-4S-center
-
 Acidaminococcus fermentans