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Literature summary extracted from

  • Hirschberg, K.; Rodger, J.; Futerman, A.H.
    The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver (1993), Biochem. J., 290, 751-757 .
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
2.3.1.24 incubation of microsomes with 0.150 mM palmitoyl CoA affects microsomal integrity since a significant reduction in the latency of mannose-6-phosphatase is observed, addition of 0.02 mM bovine serum albumin (BSA) together with palmitoyl-CoA prevents this effect. The optimum ratio of BSA to palmitoyl-CoA is determined to be 1:3-4 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.24 fumonisin B1 enzyme inhibition in vivo and in vitro Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.24 endoplasmic reticulum membrane cytosolic surface Rattus norvegicus 5789
-
2.3.1.24 microsome topology of dlhydroceramide synthesis in microsomes, overview Rattus norvegicus
-
-
2.3.1.24 additional information no endogenous activity is detected in the Golgi apparatus or plasma membrane fractions. Transport of (dihydro)-ceramide from the endoplasmic reticulum to sites of further metabolism in a pre-Golgi apparatus compartment and in the cis and medial cisternae of the Golgi apparatus Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.24 Mg2+ 1.5fold activation at 2 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.24 Rattus norvegicus
-
-
-
2.3.1.24 Rattus norvegicus Wistar
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.24 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.24 DL-erythro-sphingosine + arachidonoyl-CoA i.e. trans-D-erythro-2-amino-4-octadecene-1,3-diol Rattus norvegicus N-arachidonoyl-DL-sphingosine + CoA
-
?
2.3.1.24 DL-erythro-sphingosine + arachidonoyl-CoA i.e. trans-D-erythro-2-amino-4-octadecene-1,3-diol Rattus norvegicus Wistar N-arachidonoyl-DL-sphingosine + CoA
-
?
2.3.1.24 DL-erythro-sphingosine + palmitoyl-CoA i.e. trans-D-erythro-2-amino-4-octadecene-1,3-diol Rattus norvegicus N-palmitoyl-DL-sphingosine + CoA
-
?
2.3.1.24 DL-erythro-sphingosine + palmitoyl-CoA i.e. trans-D-erythro-2-amino-4-octadecene-1,3-diol Rattus norvegicus Wistar N-palmitoyl-DL-sphingosine + CoA
-
?
2.3.1.24 DL-erythro-sphingosine + stearoyl-CoA i.e. trans-D-erythro-2-amino-4-octadecene-1,3-diol Rattus norvegicus N-stearoyl-DL-sphingosine + CoA
-
?
2.3.1.24 DL-erythro-sphingosine + stearoyl-CoA i.e. trans-D-erythro-2-amino-4-octadecene-1,3-diol Rattus norvegicus Wistar N-stearoyl-DL-sphingosine + CoA
-
?
2.3.1.24 sphinganine + arachidonoyl-CoA i.e. DL-erythro-2-amino-1,3-octadecanediol Rattus norvegicus N-arachidonoyl-DL-dihydrosphingosine + CoA
-
?
2.3.1.24 sphinganine + arachidonoyl-CoA i.e. DL-erythro-2-amino-1,3-octadecanediol Rattus norvegicus Wistar N-arachidonoyl-DL-dihydrosphingosine + CoA
-
?
2.3.1.24 sphinganine + palmitoyl-CoA i.e. DL-erythro-2-amino-1,3-octadecanediol Rattus norvegicus N-palmitoyl-DL-dihydrosphingosine + CoA
-
?
2.3.1.24 sphinganine + palmitoyl-CoA i.e. DL-erythro-2-amino-1,3-octadecanediol Rattus norvegicus Wistar N-palmitoyl-DL-dihydrosphingosine + CoA
-
?
2.3.1.24 sphinganine + stearoyl-CoA i.e. DL-erythro-2-amino-1,3-octadecanediol Rattus norvegicus N-stearoyl-DL-dihydrosphingosine + CoA
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.24 sphinganine N-acyltransferase
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.24 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.24 7.4
-
assay at Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.3.1.24 metabolism ceramide, a key intermediate in sphingolipid metabolism, is synthesized by acylation of sphinganine followed by dehydrogenation of dihydroceramide to ceramide Rattus norvegicus