Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zouari, R.; Hamden, K.; El Feki, A.; Chaabouni, K.; Makni-Ayadi, F.; Sallemi, F.; Ellouze-Chaabouni, S.; Ghribi-Aydi, D.
    Evaluation of Bacillus subtilis SPB1 biosurfactant effects on hyperglycemia, angiotensin I-converting enzyme (ACE) activity and kidney function in rats fed on high-fat-high-fructose diet (2017), Arch. Physiol. Biochem., 123, 112-120 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 SPB1 Bacillus subtilis crude lipopeptide biosurfactant, the biosurfactant displays a potent inhibition of ACE activity in vitro, IC50 is 1.37 mg/ml Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Rattus norvegicus
-
 angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 angiotensin I + H2O Rattus norvegicus Wistar
-
 angiotensin II + L-His-L-Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Rattus norvegicus P47820
-
-
3.4.15.1 Rattus norvegicus Wistar P47820
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Rattus norvegicus angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 angiotensin I + H2O
-
 Rattus norvegicus Wistar angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.15.1 N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine + H2O
-
 Rattus norvegicus Wistar ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Rattus norvegicus
3.4.15.1 angiotensin I-converting enzyme
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.15.1 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.15.1 8
-
 assay at Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.15.1 malfunction protective and the curative effects of Bacillus subtilis SPB1 crude lipopeptide biosurfactant in alleviating induced obesity complications in rats fed on high-fat-high-fructose diet (HFFD) via inhibition of ACE activity. Administration of SPB1 biosurfactant reduced significantly (34%) the peak of blood glucose concentration 60 min after glucose administration, as compared with untreated rats fed on HFFD. SPB1 lipopeptides treatments improves some of serum electrolytes such as Na+, K+, Ca2+, and Mg2+ Rattus norvegicus