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Literature summary extracted from

  • Wu, X.; Kwon, S.J.; Kim, D.; Zha, J.; Mora-Pale, M.; Dordick, J.S.
    Unprotonated short-chain alkylamines inhibit staphylolytic activity of lysostaphin in a wall teichoic acid-dependent manner (2018), Appl. Environ. Microbiol., 84, e00693-18 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.75 expressed in Escherichia coli BL21 Star (DE3) cells Staphylococcus simulans

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.75 diethanolamine
-
Staphylococcus simulans
3.4.24.75 ethanolamine inhibits enzyme binding to the cell surface, leading to low enzyme activity, despite retention of its secondary structure. At pH 10.5 (but not at pH 7.5), methanolamine strongly deactivates the enzyme in a concentration-dependent manner Staphylococcus simulans
3.4.24.75 ethylenediamine
-
Staphylococcus simulans
3.4.24.75 triethanolamine
-
Staphylococcus simulans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.75 Staphylococcus aureus cell wall + H2O Staphylococcus simulans Staphylococcus aureus ATCC 6538 or ATCC 33807 cells ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.75 Staphylococcus simulans
-
biovar staphylolyticus
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.75 Ni-NTA agarose resin column chromatography Staphylococcus simulans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.75 Staphylococcus aureus cell wall + H2O Staphylococcus aureus ATCC 6538 or ATCC 33807 cells Staphylococcus simulans ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.75 Lst
-
Staphylococcus simulans