EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.227 | (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(2-propylpentanoyl)valinate | synthetic inhibitor based on aureobasdidin A structure, reversible | Candida albicans | |
2.7.1.227 | (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(6-phenylhexanoyl)valinate | synthetic inhibitor based on aureobasdidin A structure, reversible | Candida albicans | |
2.7.1.227 | (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-nonanoylvalinate | synthetic inhibitor based on aureobasdidin A structure, reversible | Candida albicans | |
2.7.1.227 | aureobasidin A | irreversible | Candida albicans | |
2.7.1.227 | aureobasidin A | irreversible | Saccharomyces cerevisiae | |
2.7.1.227 | khafrefungin | - |
Candida albicans | |
2.7.1.227 | khafrefungin | - |
Saccharomyces cerevisiae | |
2.7.1.227 | rustimicin | i.e. galbonolide A | Candida albicans | |
2.7.1.227 | rustimicin | i.e. galbonolide A | Saccharomyces cerevisiae |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.227 | 0.003 | - |
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine | pH 7.0, 23°C | Saccharomyces cerevisiae | |
2.7.1.227 | 0.0033 | - |
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine | pH 7.0, 23°C | Candida albicans | |
2.7.1.227 | 0.13 | - |
1-phosphatidyl-1D-myo-inositol | pH 7.0, 23°C | Candida albicans | |
2.7.1.227 | 0.555 | - |
1-phosphatidyl-1D-myo-inositol | pH 7.0, 23°C | Saccharomyces cerevisiae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.227 | Candida albicans | O13332 | - |
- |
2.7.1.227 | Candida albicans ATCC MYA-2876 | O13332 | - |
- |
2.7.1.227 | Saccharomyces cerevisiae | P36107 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.227 | 1-phosphatidyl-1D-myo-inositol + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine | - |
Saccharomyces cerevisiae | ? | - |
? | |
2.7.1.227 | 1-phosphatidyl-1D-myo-inositol + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine | - |
Candida albicans | ? | - |
? | |
2.7.1.227 | 1-phosphatidyl-1D-myo-inositol + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine | - |
Candida albicans ATCC MYA-2876 | ? | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.227 | 0.000000183 | - |
aureobasidin A | pH 7.0, 23°C | Candida albicans | |
2.7.1.227 | 0.00000023 | - |
aureobasidin A | pH 7.0, 23°C | Saccharomyces cerevisiae | |
2.7.1.227 | 0.00000043 | - |
khafrefungin | pH 7.0, 23°C | Candida albicans | |
2.7.1.227 | 0.000016 | - |
rustimicin | pH 7.0, 23°C | Candida albicans | |
2.7.1.227 | 0.008 | - |
(1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(2-propylpentanoyl)valinate | pH 7.0, 23°C | Candida albicans | |
2.7.1.227 | 0.011 | - |
(1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(6-phenylhexanoyl)valinate | pH 7.0, 23°C | Candida albicans | |
2.7.1.227 | 0.012 | - |
(1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-nonanoylvalinate | pH 7.0, 23°C | Candida albicans |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.1.227 | 0.000013 | - |
pH 7.0, 23°C | Saccharomyces cerevisiae | rustimicin | |
2.7.1.227 | 0.000043 | - |
pH 7.0, 23°C | Saccharomyces cerevisiae | khafrefungin |