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Literature summary extracted from

  • Montgomery, A.B.; Kopec, J.; Shrestha, L.; Thezenas, M.L.; Burgess-Brown, N.A.; Fischer, R.; Yue, W.W.; Venables, P.J.
    Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase implications for autoimmunity in rheumatoid arthritis (2016), Ann. Rheum. Dis., 75, 1255-1261 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.3.15 expression in Escherichia coli Porphyromonas gingivalis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.3.15 structures of wild-type and mutant C351A, to 1.46 and 1.48 A resolution. Catalysis is mediated by residues Asp130, His236, Asp238, Asn297 and Cys351. Arg152 and Arg154 may determine the substrate specificity Porphyromonas gingivalis

Protein Variants

EC Number Protein Variants Comment Organism
3.5.3.15 C351A inactive Porphyromonas gingivalis
3.5.3.15 R152A significant reduction in activity Porphyromonas gingivalis
3.5.3.15 R154A activity is similar to wild-type Porphyromonas gingivalis

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Porphyromonas gingivalis Q9RQJ2
-
-
3.5.3.15 Porphyromonas gingivalis W83 Q9RQJ2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 CESSSHHPGIAEFPS-R + H2O i.e. fibrinogen peptide FibA-R Porphyromonas gingivalis CESSSHHPGIAEFPS-citrulline + NH3
-
 ?
3.5.3.15 CESSSHHPGIAEFPS-R + H2O i.e. fibrinogen peptide FibA-R Porphyromonas gingivalis W83 CESSSHHPGIAEFPS-citrulline + NH3
-
 ?
3.5.3.15 Gly-L-Arg + H2O
-
 Porphyromonas gingivalis Gly-citrulline + NH3
-
 ?
3.5.3.15 Gly-L-Arg + H2O
-
 Porphyromonas gingivalis W83 Gly-citrulline + NH3
-
 ?
3.5.3.15 additional information no substrates: peptides Arg-Gly-Glu, Met-Arg-Phe, fibrinogen peptide CESSSHHPGIAEFPS-R-GK Porphyromonas gingivalis ?
-
 ?
3.5.3.15 additional information no substrates: peptides Arg-Gly-Glu, Met-Arg-Phe, fibrinogen peptide CESSSHHPGIAEFPS-R-GK Porphyromonas gingivalis W83 ?
-
 ?
3.5.3.15 N-alpha-benzoyl-L-arginine ethyl ester + H2O
-
 Porphyromonas gingivalis N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
 ?
3.5.3.15 N-alpha-benzoyl-L-arginine ethyl ester + H2O
-
 Porphyromonas gingivalis W83 N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.15 PPAD
-
 Porphyromonas gingivalis