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Literature summary extracted from

  • Rahier, A.
    Dissecting the sterol C-4 demethylation process in higher plants. From structures and genes to catalytic mechanism (2011), Steroids, 76, 340-352 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.18.11 expressed in Nicotiana benthamiana Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.11 stigmastan-3beta,5alpha,6alpha-triol
-
 Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.11 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.11 (3alpha,4alpha,5alpha,10alpha,13alpha,20S)-4-methyl-9,19-cycloergosta-7,24(28)-dien-3-ol + 6 ferrocytochrome b5 + 3 O2 + 6 H+
-
 Arabidopsis thaliana (3alpha,4alpha,5alpha,10alpha,13alpha,20S)-3-hydroxy-9,19-cycloergosta-7,24(28)-diene-4-carboxylic acid + 6 ferricytochrome b5 + 4 H2O
-
 ir
1.14.18.11 (3alpha,4alpha,5alpha,10alpha,13alpha,20S)-4-methylcholest-7-en-3-ol + 6 ferrocytochrome b5 + 3 O2 + 6 H+
-
 Arabidopsis thaliana (3alpha,4alpha,5alpha,10alpha,13alpha,20S)-3-hydroxycholest-7-ene-4-carboxylic acid + 6 ferricytochrome b5 + 4 H2O
-
 ir
1.14.18.11 24-ethylidenelophenol + 6 ferrocytochrome b5 + 3 O2 + 6 H+
-
 Arabidopsis thaliana 3beta,4alpha,5alpha-3-hydroxystigmasta-7,24(28)-diene-4-carboxylate + 6 ferricytochrome b5 + 4 H2O
-
 ?
1.14.18.11 24-methylidenelophenol + 6 ferrocytochrome b5 + 3 O2 + 6 H+
-
 Arabidopsis thaliana 3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + 6 ferricytochrome b5 + 4 H2O
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.14.18.11 4alpha-methyl-DELTA7-sterol-4alpha-methyl-oxidase
-
 Arabidopsis thaliana
1.14.18.11 4alpha-methylsterol-4alpha-methyl-oxidase
-
 Arabidopsis thaliana
1.14.18.11 SMO2
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
1.14.18.11 malfunction when silencing the enzyme, an important accumulation of 4alpha-methyl-DELTA7-sterols is found, with no change in the levels of 4,4-dimethylsterols Arabidopsis thaliana
1.14.18.11 metabolism the enzyme is involved in the removal of the second C4-methyl group of phytosterol precursors Arabidopsis thaliana