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Literature summary extracted from

  • Al-Haj, L.; Khabar, K.S.A.
    The intracellular pyrimidine 5'-nucleotidase NT5C3A is a negative epigenetic factor in interferon and cytokine signaling (2018), Sci. Signal., 11, eaal2434 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.5 a 5'-ribonucleotide + H2O Homo sapiens
-
a ribonucleoside + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.5 2fTGH cell
-
Homo sapiens
-
3.1.3.5 A-549 cell
-
Homo sapiens
-
3.1.3.5 DAUDI cell
-
Homo sapiens
-
3.1.3.5 fibroblast
-
Homo sapiens
-
3.1.3.5 HEK-293 cell
-
Homo sapiens
-
3.1.3.5 HeLa cell
-
Homo sapiens
-
3.1.3.5 HT-1080 cell
-
Homo sapiens
-
3.1.3.5 Huh-7 cell
-
Homo sapiens
-
3.1.3.5 THP-1 cell
-
Homo sapiens
-
3.1.3.5 umbilical vein endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.5 a 5'-ribonucleotide + H2O
-
Homo sapiens a ribonucleoside + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.3.5 ? x * 38000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.5 NT5C3A
-
Homo sapiens
3.1.3.5 PN-1
-
Homo sapiens
3.1.3.5 pyrimidine 5'-nucleotidase
-
Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.3.5 malfunction enzyme knockdown enhances tumor necrosis factor-stimulated interleukin-8 production Homo sapiens
3.1.3.5 physiological function enzyme overexpression increases the abundance of NAD+ and the activation of the sirtuins SIRT1 and SIRT6 Homo sapiens