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Literature summary extracted from

  • Shiraishi, M.; Ishino, S.; Yoshida, K.; Yamagami, T.; Cann, I.; Ishino, Y.
    PCNA is involved in the EndoQ-mediated DNA repair process in Thermococcales (2016), Sci. Rep., 6, 25532 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.21.B1 proliferating cell nuclear antigen activity is enhanced by addition of Proliferating Cell Nuclear Antigen (PCNA) in vitro. The physical interaction between the two proteins through a PIP-motif of EndoQ and the toroidal structure of PCNA are critical for the stimulation of the endonuclease activity Pyrococcus furiosus
3.1.21.B1 proliferating cell nuclear antigen activity is enhanced by addition of Proliferating Cell Nuclear Antigen (PCNA) in vitro. The physical interaction between the two proteins through a PIP-motif of EndoQ and the toroidal structure of PCNA are critical for the stimulation of the endonuclease activity Thermococcus kodakarensis

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.B1 Pyrococcus furiosus Q8U0N5
-
-
3.1.21.B1 Pyrococcus furiosus ATCC 43587 Q8U0N5
-
-
3.1.21.B1 Thermococcus kodakarensis Q5JI33
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.21.B1 DNA + H2O the enzyme recognizes uracil, abasic site and xanthine, as well as hypoxanthine, and cuts the phosphodiester bond at their 5' sides Pyrococcus furiosus ?
-
 ?
3.1.21.B1 DNA + H2O the enzyme recognizes uracil, abasic site and xanthine, as well as hypoxanthine, and cuts the phosphodiester bond at their 5' sides Thermococcus kodakarensis ?
-
 ?
3.1.21.B1 DNA + H2O the enzyme recognizes uracil, abasic site and xanthine, as well as hypoxanthine, and cuts the phosphodiester bond at their 5' sides Pyrococcus furiosus ATCC 43587 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.21.B1 EndoQ
-
 Pyrococcus furiosus
3.1.21.B1 EndoQ
-
 Thermococcus kodakarensis