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Literature summary extracted from

  • Haikarainen, T.; Lehtioe, L.
    Proximal ADP-ribose hydrolysis in Trypanosomatids is catalyzed by a macrodomain (2016), Sci. Rep., 6, 24213 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.106 expressed in Escherichia coli BL21(DE3) cells Trypanosoma cruzi
3.1.1.106 expressed in Escherichia coli BL21(DE3) cells Trypanosoma brucei gambiense

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.1.106 apoenzyme and in complex with ADP-D-ribose or ADP, sitting drop vapor diffusion method, using 20-25% (w/v) PEG 3350 Trypanosoma brucei gambiense
3.1.1.106 apoenzyme, sitting drop vapor diffusion method, using 0.1 M Bis-Tris propane pH 8.0, 0.96 M trisodium citrate Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O Trypanosoma cruzi
-
 ADP-D-ribose + acetate
-
 ?
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O Trypanosoma brucei gambiense
-
 ADP-D-ribose + acetate
-
 ?
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O Trypanosoma cruzi CL Brener
-
 ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O Trypanosoma cruzi
-
 ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O Trypanosoma brucei gambiense
-
 ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O Trypanosoma cruzi CL Brener
-
 ADP-D-ribose + acetate
-
 ?
3.1.1.106 [protein]-ADP-D-ribose + H2O Trypanosoma cruzi
-
 [protein] + ADP-D-ribose
-
 ?
3.1.1.106 [protein]-ADP-D-ribose + H2O Trypanosoma brucei gambiense
-
 [protein] + ADP-D-ribose
-
 ?
3.1.1.106 [protein]-ADP-D-ribose + H2O Trypanosoma cruzi CL Brener
-
 [protein] + ADP-D-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.106 Trypanosoma brucei gambiense C9ZP98
-
-
3.1.1.106 Trypanosoma cruzi Q4DQ03
-
-
3.1.1.106 Trypanosoma cruzi CL Brener Q4DQ03
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.106 HisTrap column chromatography and Superdex 75 gel filtration Trypanosoma cruzi
3.1.1.106 HisTrap column chromatography and Superdex 75 gel filtration Trypanosoma brucei gambiense

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma cruzi ADP-D-ribose + acetate
-
 ?
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma brucei gambiense ADP-D-ribose + acetate
-
 ?
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma cruzi CL Brener ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma cruzi ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma brucei gambiense ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma cruzi CL Brener ADP-D-ribose + acetate
-
 ?
3.1.1.106 [protein]-ADP-D-ribose + H2O
-
 Trypanosoma cruzi [protein] + ADP-D-ribose
-
 ?
3.1.1.106 [protein]-ADP-D-ribose + H2O
-
 Trypanosoma brucei gambiense [protein] + ADP-D-ribose
-
 ?
3.1.1.106 [protein]-ADP-D-ribose + H2O
-
 Trypanosoma cruzi CL Brener [protein] + ADP-D-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.106 ADP-ribose hydrolase
-
 Trypanosoma cruzi
3.1.1.106 ADP-ribose hydrolase
-
 Trypanosoma brucei gambiense
3.1.1.106 MacroD-like protein
-
 Trypanosoma cruzi
3.1.1.106 MacroD-like protein
-
 Trypanosoma brucei gambiense
3.1.1.106 MDO
-
 Trypanosoma cruzi
3.1.1.106 MDO
-
 Trypanosoma brucei gambiense