Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fu, Z.; Abou-Samra, A.B.; Zhang, R.
    A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase (2015), Sci. Rep., 5, 18502 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.34 triacylglycerol + H2O Mus musculus
-
 diacylglycerol + a carboxylate
-
 ?
3.1.1.34 triacylglycerol + H2O Mus musculus BALB/c
-
 diacylglycerol + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.34 Mus musculus P11152
-
-
3.1.1.34 Mus musculus BALB/c P11152
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.34 cardiac muscle
-
 Mus musculus
-
3.1.1.34 heart
-
 Mus musculus
-
3.1.1.34 skeletal muscle
-
 Mus musculus
-
3.1.1.34 white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.34 triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate
-
 ?
3.1.1.34 triacylglycerol + H2O
-
 Mus musculus BALB/c diacylglycerol + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.34 LPL
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.1.1.34 Mus musculus lipasin suppresses the activity of LPL specifically in cardiac and skeletal muscles down

General Information

EC Number General Information Comment Organism
3.1.1.34 physiological function lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase. Lipasin/Angptl8 is a feeding-induced hepatokine that regulates triglyceride (TAG) metabolism. Lipasin-deficient mice exhibit elevated postprandial activity of LPL in the heart and skeletal muscle, but not in white adipose tissue, suggesting that lipasin suppresses the activity of LPL specifically in cardiac and skeletal muscles. During fasting, LPL activity is upregulated in the heart and skeletal muscle, which, in turn, take up fatty acids for energy production. In the fed state, LPL activity is upregulated in white adipose tissue, which, in turn, takes up fatty acids for storage Mus musculus