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Literature summary extracted from

  • Swygert, S.G.; Senapati, S.; Bolukbasi, M.F.; Wolfe, S.A.; Lindsay, S.; Peterson, C.L.
    SIR proteins create compact heterochromatin fibers (2018), Proc. Natl. Acad. Sci. USA, 115, 12447-12452 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 [histone H4]-N6-acetyl-L-lysine16 + NAD+ + H2O overall reaction Saccharomyces cerevisiae [histone H4]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 Sir2
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 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.3.1.286 physiological function heterochromatin assembly requires the SIR proteins Sir3, the primary structural component of SIR heterochromatin, and the Sir2-4 complex, responsible for the targeted recruitment of SIR proteins and the deacetylation of lysine 16 of histone H4 Saccharomyces cerevisiae