EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.2.1.45 | additional information | a lysosomal integral membrane protein type-2 helix 5-derived peptide fused to a cellpenetrating peptide can be used to activate endogenous as well as recombinant wild-type or mutant enzyme efficiently | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.2.1.45 | F213I | the mutation is associated with Gaucher's disease | Homo sapiens |
3.2.1.45 | I161S | the mutation is associated with Gaucher's disease | Homo sapiens |
3.2.1.45 | L156E | the mutant shows strongly reduced activity compared to the wild type enzyme | Homo sapiens |
3.2.1.45 | L91E | the mutant shows strongly reduced activity compared to the wild type enzyme | Homo sapiens |
3.2.1.45 | L94E | the mutant shows strongly reduced activity compared to the wild type enzyme | Homo sapiens |
3.2.1.45 | N188S | the mutation is associated with Gaucher's disease | Homo sapiens |
3.2.1.45 | N370S | the mutation is associated with Gaucher's disease | Homo sapiens |
3.2.1.45 | P159L | the mutation is associated with Gaucher's disease | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.2.1.45 | lysosome | - |
Homo sapiens | 5764 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.1.45 | Homo sapiens | P04062 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.1.45 | 4-methylumbelliferyl beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-glucopyranose | - |
? | |
3.2.1.45 | 4-nitrophenyl beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-nitrophenol + beta-D-glucopyranose | - |
? | |
3.2.1.45 | 4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O | - |
Homo sapiens | 4-nitrophenol + N-acetyl-beta-D-glucosamine | - |
? | |
3.2.1.45 | 5-(pentafluorobenzoylamino)fluorescein di-beta-D-glucopyranoside + H2O | - |
Homo sapiens | 5-(pentafluorobenzoylamino)fluorescein + 2 beta-D-glucopyranose | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.2.1.45 | ? | x * 60000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.1.45 | beta-glucocerebrosidase | - |
Homo sapiens |