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Literature summary extracted from

  • Corrigan, R.; Abbott, J.; Burhenne, H.; Kaever, V.; Gruendling, A.
    C-di-amp is a new second messenger in staphylococcus aureus with a role in controlling cell size and envelope stress (2011), PLoS Pathog., 7, e1002217 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.59 Staphylococcus aureus
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-
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3.1.4.59 Staphylococcus aureus RN4220
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.59 cyclic di-3',5'-adenylate + H2O
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 Staphylococcus aureus 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
3.1.4.59 cyclic di-3',5'-adenylate + H2O
-
 Staphylococcus aureus RN4220 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.59 gdpP
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 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
3.1.4.59 physiological function mutations within the GdpP gene, allow both laboratory and clinical isolates of Staphylococcus aureus to grow without lipoteichoic acid. Intracellular c-di-AMP levels increase drastically in GdpP deletion strains and in an lipoteichoic acid-deficient suppressor strain. An increased amount of cross-linked peptidoglycan is observed in the GdpP mutant strain. GdpP mutant strains display a 13-22% reduction in the cell size due to increased c-di-AMP levels Staphylococcus aureus