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Literature summary extracted from

  • El Moussawi, L.; Chakkour, M.; Kreydiyyeh, S.I.
    Epinephrine modulates Na+/K+ ATPase activity in Caco-2 cells via Src, p38MAPK, ERK and PGE2 (2018), PLoS ONE, 13, e0193139 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 epinephrine 0.5 mM epinephrine added for 20 min, decreases the activity of the enzyme by around 50%. Treatment with Rp-cAMP, indomethacin, PP2, SB202190, and PD98059 completely abrogate the effect of epinephrine Homo sapiens
7.2.2.13 Ouabain specific inhibitor Homo sapiens
7.2.2.13 prostaglandin E2
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ATP + H2O + 3 Na+[side 1] + 2 K+[side 2] Homo sapiens
-
 ADP + phosphate + 3 Na+[side 2] + 2 K+[side 1]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 Caco-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ATP + H2O + 3 Na+[side 1] + 2 K+[side 2]
-
 Homo sapiens ADP + phosphate + 3 Na+[side 2] + 2 K+[side 1]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na+/K+ ATPase
-
 Homo sapiens