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Literature summary extracted from

  • Sharma, M.; Iyer, J.K.; Shih, N.; Majumder, M.; Mattaparthi, V.S.; Mukhopadhyay, R.; Doley, R.
    Daboxin P, a major phospholipase A2 enzyme from the Indian Daboia russelii russelii venom targets factor X and factor Xa for its anticoagulant activity (2016), PLoS ONE, 11, e0153770 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 4-bromophenacyl bromide alkylation with 4-bromophenacyl bromide leads to the complete loss of its enzymatic activity signifying the crucial role of histidine residue in catalysis Daboia russelii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.4 13597
-
 electrospray ionization mass spectrometry Daboia russelii

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Daboia russelii C0HK16
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4
-
 Daboia russelii

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 venom
-
 Daboia russelii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1,2-diheptanoylthio-phosphatidylcholine + H2O
-
 Daboia russelii ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 Daboxin P
-
 Daboia russelii

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.1.4 72
-
 Tm value is 71.59°C Daboia russelii

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.1.1.4 3
-
 stable at Daboia russelii
3.1.1.4 7
-
 stable at Daboia russelii

General Information

EC Number General Information Comment Organism
3.1.1.4 physiological function the crude venom of Daboia r. russelii has prominent cytotoxic effect on HEK-293 and MCF-7 cells in a dose dependent manner. Phospholipase A2 enzyme from Indian viper (Daboia russelii russelii) venom targets both factor X and factor Xa for its anticoagulant activity Daboia russelii