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Literature summary extracted from

  • Berdan, C.A.; Erion, K.A.; Burritt, N.E.; Corkey, B.E.; Deeney, J.T.
    Inhibition of monoacylglycerol lipase activity decreases glucose-stimulated insulin secretion in INS-1 (832/13) cells and rat islets (2016), PLoS ONE, 11, e0149008 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 JZL184 significantly decreases lipolysis and increases both mono- and diacyglycerol species in INS-1 cells. Analysis of the kinetics of glucose-stimulated insulin secretion (GSIS) shows that inhibition is greater during the sustained phase of secretion. JZL184 does not significantly affect basal insulin secretion at any concentration tested. Kinetics, overview Rattus norvegicus
3.1.1.23 MJN110 inhibits glucose-stimulated insulin secretion and depolarization-induced insulin secretion in INS-1 (832/13) cells Rattus norvegicus
3.1.1.23 URB602 inhibits glucose-stimulated insulin secretion and depolarization-induced insulin secretion in INS-1 (832/13) cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.23 cytosol
-
 Rattus norvegicus 5829
-
3.1.1.23 plasma membrane
-
 Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.23 monoacylglycerol + H2O Rattus norvegicus
-
 acylic acid + glycerol
-
 ?
3.1.1.23 monoacylglycerol + H2O Rattus norvegicus Sprague-Dawley
-
 acylic acid + glycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Rattus norvegicus Q8R431
-
-
3.1.1.23 Rattus norvegicus Sprague-Dawley Q8R431
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 INS-1 cell
-
 Rattus norvegicus
-
3.1.1.23 pancreas
-
 Rattus norvegicus
-
3.1.1.23 pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 monoacylglycerol + H2O
-
 Rattus norvegicus acylic acid + glycerol
-
 ?
3.1.1.23 monoacylglycerol + H2O
-
 Rattus norvegicus Sprague-Dawley acylic acid + glycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 monoacylglycerol lipase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.23 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.23 7.4
-
 assay at Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.1.1.23 malfunction inhibition of monoacylglycerol lipase activity decreases glucose-stimulated insulin secretion in INS-1 (832/13) cells and rat islets Rattus norvegicus
3.1.1.23 physiological function monoacylglycerol lipase (MGL) activity catalyzes the final step in triacylglycerol breakdown, namely the hydrolysis of monoacylglycerol to glycerol and free fatty acid. The final common step in the triggering pathway of glucose-stimulated insulin secretion (GSIS) and depolarization is a rise in cytosolic Ca2+, which directly promotes the fusion of insulin granules with the plasma membrane. The ability of JZL184 to inhibit both GSIS and KCl/DZ induced insulin secretion implied a strong likelihood that Ca2+ is reduced in response to these stimuli Rattus norvegicus