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Literature summary extracted from

  • Segal-Salto, M.; Sapir, T.; Reiner, O.
    Reversible cysteine acylation regulates the activity of human Palmitoyl-Protein Thioesterase 1 (PPT1) (2016), PLoS ONE, 11, e0146466 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.22 expressed in COS-7 and HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.2.22 C6S the activity of the non-palmitoylatable mutant significantly surpasses that of the wild type enzyme by more than 42% in the cell lysate and 25% in the cell medium Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.22 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.1.2.22 Golgi apparatus
-
 Homo sapiens 5794
-
3.1.2.22 lysosome
-
 Homo sapiens 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.22 Homo sapiens P50897
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.2.22 palmitoylation the enzyme is palmitoylated at Cys-6 by DHHC3 and DHHC7 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.22 4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O
-
 Homo sapiens palmitate + 4-methylumbelliferyl 6-thio-beta-D-glucoside
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.22 ? x * 35000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.2.22 palmitoyl-protein thioesterase 1
-
 Homo sapiens
3.1.2.22 PPT1
-
 Homo sapiens