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Literature summary extracted from

  • Seo, J.B.; Jung, S.R.; Huang, W.; Zhang, Q.; Koh, D.S.
    Charge shielding of PIP2 by cations regulates enzyme activity of phospholipase C (2015), PLoS ONE, 10, e0144432 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 additional information spermine does not stimulate the activity of isoform PLCbeta1 Homo sapiens
3.1.4.11 spermine spermine potentiates the activity of isoform PLCgamma1 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 Ba2+
-
 Homo sapiens
3.1.4.11 Mg2+
-
 Homo sapiens
3.1.4.11 neomycin neomycin does not inhibit the enzyme activity completely Homo sapiens
3.1.4.11 putrescine putrescine is less efficient than divalent cations in reducing isoform PLCbeta1 activity Homo sapiens
3.1.4.11 spermidine
-
 Homo sapiens
3.1.4.11 spermine
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+ stimulates activity of isoform PLCbeta1 with saturation at 0.02 mM Ca2+ Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 1,4,5-triphosphate + diacylglycerol
-
 ?
3.1.4.11 1D-myo-inositol 1,4,5-trisphosphate fluorescent derivative WH-15 + H2O
-
 Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + quinomethide + 6-aminoquinoline + ?
-
 ir

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 phospholipase C
-
 Homo sapiens
3.1.4.11 PLCbeta1 isoform Homo sapiens
3.1.4.11 PLCdelta1 isoform Homo sapiens
3.1.4.11 PLCgamma1 isoform Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.11 0.006
-
 isoform PLCdelta1, at pH 7.3 and 25°C Homo sapiens neomycin
3.1.4.11 0.011
-
 isoform PLCbeta1, at pH 7.3 and 25°C Homo sapiens neomycin
3.1.4.11 0.024
-
 isoform PLCgamma1, at pH 7.3 and 25°C Homo sapiens neomycin
3.1.4.11 0.4
-
 isoform PLCbeta1, at pH 7.3 and 25°C Homo sapiens spermine
3.1.4.11 1.7
-
 isoform PLCdelta1, at pH 7.3 and 25°C Homo sapiens spermine
3.1.4.11 4
-
 isoform PLCgamma1, at pH 7.3 and 25°C Homo sapiens spermine