Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ohtsu, I.; Kawano, Y.; Suzuki, M.; Morigasaki, S.; Saiki, K.; Yamazaki, S.; Nonaka, G.; Takagi, H.
    Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli (2015), PLoS ONE, 10, e0120619 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.4.2.12 0.0000496
-
 L-cystine-[cystine-binding protein][side 1] at pH 6.5 and 37°C Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.4.2.12 membrane
-
 Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein][side 1] Escherichia coli
-
 ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.12 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein][side 1]
-
 Escherichia coli ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.12 FliY-YecSC
-
 Escherichia coli
7.4.2.12 L-cystine transporter
-
 Escherichia coli

Expression

EC Number Organism Comment Expression
7.4.2.12 Escherichia coli enzyme expression is induced by H2O2 up

General Information

EC Number General Information Comment Organism
7.4.2.12 metabolism the enzyme imports L-cystine from the periplasm to the cytoplasm Escherichia coli
7.4.2.12 physiological function the enzyme contributes to hydrogen peroxide tolerance. The L-cystine/L-cystine shuttle system plays a role of detoxification of hydrogen peroxide before lipid peroxidation occurs, and then specifically prevents damage to membrane lipids Escherichia coli