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Literature summary extracted from

  • Baccolini, C.; Witte, C.P.
    AMP and GMP catabolism in Arabidopsis converge on xanthosine, which is degraded by a nucleoside hydrolase heterocomplex (2019), Plant Cell, 31, 734-751 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.15 guanosine + H2O Arabidopsis thaliana
-
 xanthosine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.3 Arabidopsis thaliana Q9SJM7
-
-
3.5.4.15 Arabidopsis thaliana Q94BU8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.15 guanosine + H2O
-
 Arabidopsis thaliana xanthosine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.3 NSH1
-
 Arabidopsis thaliana
3.2.2.3 nucleoside hydrolase 1
-
 Arabidopsis thaliana
3.2.2.3 URH1
-
 Arabidopsis thaliana
3.5.4.15 At5g28050
-
 Arabidopsis thaliana
3.5.4.15 GSDA
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
3.2.2.3 physiological function nucleoside hydrolase NSH1 activates NSH2 in vitro and in vivo, forming a complex with almost two orders of magnitude higher catalytic efficiency for xanthosine hydrolysis than observed for NSH1 alone. An inactive NSH1 point mutant can activate NSH2 in vivo, fully preventing purine nucleoside accumulation in Nsh1 mutant background Arabidopsis thaliana
3.5.4.15 metabolism purine nucleotide catabolism depends to a great extent on the guanosine deaminase reaction Arabidopsis thaliana