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Literature summary extracted from

  • Singh, N.; Yadav, S.; Rathaur, S.
    Identification and characterization of novel membrane-bound PRL protein tyrosine phosphatases from Setaria cervi, a bovine filarial parasite (2015), Parasitol. Res., 114, 4267-4279 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.48 DTT highly activating at 2 mM Setaria cervi

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 1,2-Cyclohexanedione 40% inhibition at 1 mM Setaria cervi
3.1.3.48 1-ethyl-3-dimethylaminopropyl carbodiimide 90% inhibition at 25 mM Setaria cervi
3.1.3.48 4-hydroxymercuribenzoate 62% inhibition at 2.5 mM Setaria cervi
3.1.3.48 Acetylsalicylic acid 80% inhibition at 0.2 mM Setaria cervi
3.1.3.48 Ag+ 62% inhibition at 2.5 mM Setaria cervi
3.1.3.48 Ammonium molybdate 98% inhibition at 2 mM Setaria cervi
3.1.3.48 cantharidin 17% inhibition at 1 mM Setaria cervi
3.1.3.48 diethylcarbamazine 12% inhibition at 0.2 mM Setaria cervi
3.1.3.48 diethyldicarbonate 7% inhibition at 1 mM Setaria cervi
3.1.3.48 EDTA 51% inhibition at 5 mM Setaria cervi
3.1.3.48 iodoacetic acid complete inhibition at 1.0 mM Setaria cervi
3.1.3.48 L-(+)-Tartrate 6.5% inhibition at 5 mM Setaria cervi
3.1.3.48 okadaic acid 7.5% inhibition at 0.01 mM Setaria cervi
3.1.3.48 Phenylarsine oxide a specific PTP inhibitor, 79% inhibition at 1.0 nM Setaria cervi
3.1.3.48 SK7 a metal chalcone, complete inhibition at 0.02 mM Setaria cervi
3.1.3.48 Sodium fluoride 96% inhibition at 2 mM Setaria cervi
3.1.3.48 sodium orthovanadate 99.5% inhibition at 0.05 mM Setaria cervi
3.1.3.48 Zn2+ 65.5% inhibition at 2.5 mM Setaria cervi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.48 membrane bound Setaria cervi 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.48 Ca2+ activates at 2.5 mM Setaria cervi
3.1.3.48 Mg2+ activates slightly at 2.5 mM Setaria cervi
3.1.3.48 Mn2+ activates at 2.5 mM Setaria cervi

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.48 21000
-
gel filtration Setaria cervi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O Setaria cervi
-
[a protein]-tyrosine + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Setaria cervi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.48 native enzyme from adult females by concanavalin A affinity chromatography and cation exchange chromatography to homogeneity Setaria cervi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 4-nitrophenyl phosphate + H2O acid phosphatase activity, best tested substrate Setaria cervi 4-nitrophenol + phosphate
-
?
3.1.3.48 additional information substrate specificity of enzyme PRL, overview. The enzyme also hydrolyzes adenosine diphosphate, fructose 6-phosphate, sodium alpha-naphthyl phosphate, and phosphoenol pyruvate Setaria cervi ?
-
?
3.1.3.48 O-phospho-L-serine + H2O very low activity with Setaria cervi L-serine + phosphate
-
?
3.1.3.48 O-phospho-L-threonine + H2O
-
Setaria cervi L-threonine + phosphate
-
?
3.1.3.48 O-phospho-L-tyrosine + H2O
-
Setaria cervi L-tyrosine + phosphate
-
?
3.1.3.48 [a protein]-tyrosine phosphate + H2O
-
Setaria cervi [a protein]-tyrosine + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.3.48 monomer 1 * 21000, SDS-PAGE, 1 * 20527, mass spectrometry Setaria cervi

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 acid phosphatase activity
-
Setaria cervi
3.1.3.48 PRL
-
Setaria cervi
3.1.3.48 protein tyrosine phosphatase
-
Setaria cervi
3.1.3.48 PTP
-
Setaria cervi

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.48 37
-
-
Setaria cervi

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.1.3.48
-
80 activity range, profile overview, maximal activity at 37°C Setaria cervi

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.3.48 60
-
the enzyme is almost denatured at 60°C Setaria cervi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.48 5.5
-
-
Setaria cervi

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.48 3.5 8 activity range, profile overview, maximal activity at pH 5.5 Setaria cervi

Expression

EC Number Organism Comment Expression
3.1.3.48 Setaria cervi the enzyme is slightly upregulated at oxidative stress generated by a Fe2+/H2O2/ascorbate system up

General Information

EC Number General Information Comment Organism
3.1.3.48 additional information the purified enzyme seems to harbor Cys, His, Asp, and Arg residues in its active site Setaria cervi