Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Massimo, A.; Maura, S.; Nicoletta, L.; Giulia, M.; Valentina, M.; Elena, C.; Alessandro, P.; Rosaria, B.; Sandro, S.
    Current and novel aspects on the non-lysosomal beta-glucosylceramidase GBA2 (2016), Neurochem. Res., 41, 210-220 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.45 acetazolamide
-
 Homo sapiens
3.2.1.45 EGTA
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.45 expressed in COS-7 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.45 5-(N-ethyl-N-isopropyl)amiloride
-
 Homo sapiens
3.2.1.45 conduritol B epoxide isoform GBA2 is inactivated by conduritol B epoxide in a time-dependent manner. When 0.5 mM conduritol B epoxide is administered to cultured cells for 2 days, isoform GBA2 activity is reduced about 50-60% Homo sapiens
3.2.1.45 deoxynojirimycin
-
 Homo sapiens
3.2.1.45 esomeprazole
-
 Homo sapiens
3.2.1.45 N-(5-adamantane-1-yl-methoxypentyl)deoxynojirimycin most powerful inhibitor of isoform GBA2 Homo sapiens
3.2.1.45 N-butyl deoxynojirimycin miglustat or Zavesca Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.45 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.2.1.45 Golgi apparatus
-
 Homo sapiens 5794
-
3.2.1.45 plasma membrane cytosolic side of membranes Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.45 glucocerebroside + H2O Homo sapiens
-
 D-glucose + ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.45 Homo sapiens Q9HCG7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.45 cerebrum
-
 Homo sapiens
-
3.2.1.45 colon
-
 Homo sapiens
-
3.2.1.45 forebrain highest activity Homo sapiens
-
3.2.1.45 glioma cell
-
 Homo sapiens
-
3.2.1.45 heart
-
 Homo sapiens
-
3.2.1.45 hepatoma cell
-
 Homo sapiens
-
3.2.1.45 kidney
-
 Homo sapiens
-
3.2.1.45 leukocyte
-
 Homo sapiens
-
3.2.1.45 liver
-
 Homo sapiens
-
3.2.1.45 lung
-
 Homo sapiens
-
3.2.1.45 lymphocyte
-
 Homo sapiens
-
3.2.1.45 neuroblastoma cell
-
 Homo sapiens
-
3.2.1.45 placenta
-
 Homo sapiens
-
3.2.1.45 skeletal muscle
-
 Homo sapiens
-
3.2.1.45 skin fibroblast
-
 Homo sapiens
-
3.2.1.45 small intestine
-
 Homo sapiens
-
3.2.1.45 spleen
-
 Homo sapiens
-
3.2.1.45 thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.45 4-methylumbelliferyl beta-D-glucopyranoside + H2O
-
 Homo sapiens 4-methylumbelliferone + beta-D-glucopyranose
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Homo sapiens D-glucose + ceramide
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.45 ? x * 104000, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.2.1.45 beta-glucosidase 2
-
 Homo sapiens
3.2.1.45 GBA2
-
 Homo sapiens
3.2.1.45 microsomal bile acid beta-glucosidase
-
 Homo sapiens
3.2.1.45 non-lysosomal beta-glucosylceramidase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.45 5.8
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.2.1.45 5 7.5 the enzyme shows more than 50% activity between pH 5.0 and 7.5 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.45 8.1
-
 conduritol B epoxide pH and temperature not specified in the publication Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.2.1.45 Homo sapiens calculated from amino acid sequence
-
 5.6