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Literature summary extracted from

  • Igawa, Y.; Fujiwara, S.; Ohura, K.; Hirokawa, T.; Nishizawa, Y.; Uehara, S.; Uno, Y.; Imai, T.
    Differences in intestinal hydrolytic activities between cynomolgus monkeys and humans evaluation of substrate specificities using recombinant carboxylesterase 2 isozymes (2016), Mol. Pharm., 13, 3176-3186 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.1 additional information
-
 additional information kinetics Homo sapiens
3.1.1.1 additional information
-
 additional information kinetics Macaca fascicularis
3.1.1.1 0.0024
-
 (R)-propranolyl 3-methylbutanoate enzyme hCE2, pH and temperature not specified in the publication Homo sapiens
3.1.1.1 0.004
-
 (S)-propranolyl 3-methylbutanoate enzyme hCE2, pH and temperature not specified in the publication Homo sapiens
3.1.1.1 0.0045
-
 (S)-propranolyl 2-methylbutanoate enzyme mfCES2v3, pH and temperature not specified in the publication Macaca fascicularis
3.1.1.1 0.0066
-
 (S)-propranolyl n-valerate enzyme mfCES2v3, pH and temperature not specified in the publication Macaca fascicularis
3.1.1.1 0.0072
-
 (R)-propranolyl 3-methylbutanoate enzyme mfCES2v3, pH and temperature not specified in the publication Macaca fascicularis
3.1.1.1 0.009
-
 (S)-propranolyl 3-methylbutanoate enzyme mfCES2v3, pH and temperature not specified in the publication Macaca fascicularis
3.1.1.1 0.0106
-
 (R)-propranolyl n-valerate enzyme mfCES2v3, pH and temperature not specified in the publication Macaca fascicularis
3.1.1.1 0.012
-
 (R)-propranolyl n-valerate enzyme hCE2, pH and temperature not specified in the publication Homo sapiens
3.1.1.1 0.0125
-
 (R)-propranolyl 2-methylbutanoate enzyme hCE2, pH and temperature not specified in the publication Homo sapiens
3.1.1.1 0.0132
-
 (R)-propranolyl 2-methylbutanoate enzyme mfCES2v3, pH and temperature not specified in the publication Macaca fascicularis
3.1.1.1 0.0149
-
 (S)-propranolyl 2-methylbutanoate enzyme hCE2, pH and temperature not specified in the publication Homo sapiens
3.1.1.1 0.0178
-
 (S)-propranolyl n-valerate enzyme hCE2, pH and temperature not specified in the publication Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.1 microsome
-
 Homo sapiens
-
-
3.1.1.1 microsome
-
 Macaca fascicularis
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Homo sapiens O00748
-
-
3.1.1.1 Macaca fascicularis A0A2K5V282
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 intestine
-
 Homo sapiens
-
3.1.1.1 intestine
-
 Macaca fascicularis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 (R)-propranolyl 2-methyl-n-valerate + H2O
-
 Homo sapiens (R)-propranolol + 2-methylpentanoate
-
 ?
3.1.1.1 (R)-propranolyl 2-methyl-n-valerate + H2O
-
 Macaca fascicularis (R)-propranolol + 2-methylpentanoate
-
 ?
3.1.1.1 (R)-propranolyl 2-methylbutanoate + H2O
-
 Homo sapiens (R)-propranolol + 2-methylbutanoate
-
 ?
3.1.1.1 (R)-propranolyl 2-methylbutanoate + H2O
-
 Macaca fascicularis (R)-propranolol + 2-methylbutanoate
-
 ?
3.1.1.1 (R)-propranolyl 3-methylbutanoate + H2O
-
 Homo sapiens (R)-propranolol + 3-methylbutanoate
-
 ?
3.1.1.1 (R)-propranolyl 3-methylbutanoate + H2O
-
 Macaca fascicularis (R)-propranolol + 3-methylbutanoate
-
 ?
3.1.1.1 (R)-propranolyl 3-methylpentanoate + H2O
-
 Homo sapiens (R)-propranolol + 3-methylpentanoate
-
 ?
3.1.1.1 (R)-propranolyl 3-methylpentanoate + H2O
-
 Macaca fascicularis (R)-propranolol + 3-methylpentanoate
-
 ?
3.1.1.1 (R)-propranolyl hexanoate + H2O
-
 Homo sapiens (R)-propranolol + hexanoate
-
 ?
3.1.1.1 (R)-propranolyl hexanoate + H2O
-
 Macaca fascicularis (R)-propranolol + hexanoate
-
 ?
3.1.1.1 (R)-propranolyl n-valerate + H2O
-
 Homo sapiens (R)-propranolol + pentanoate
-
 ?
3.1.1.1 (R)-propranolyl n-valerate + H2O
-
 Macaca fascicularis (R)-propranolol + pentanoate
-
 ?
3.1.1.1 (S)-propranolol 3-methylpentanoate + H2O
-
 Homo sapiens (S)-propranolol + 3-methylpentanoate
-
 ?
3.1.1.1 (S)-propranolol 3-methylpentanoate + H2O
-
 Macaca fascicularis (S)-propranolol + 3-methylpentanoate
-
 ?
3.1.1.1 (S)-propranolyl 2-methylbutanoate + H2O
-
 Homo sapiens (S)-propranolol + 2-methylbutanoate
-
 ?
3.1.1.1 (S)-propranolyl 2-methylbutanoate + H2O
-
 Macaca fascicularis (S)-propranolol + 2-methylbutanoate
-
 ?
3.1.1.1 (S)-propranolyl 2-methylpentanoate + H2O
-
 Homo sapiens (S)-propranolol + 2-methylpentanoate
-
 ?
3.1.1.1 (S)-propranolyl 2-methylpentanoate + H2O
-
 Macaca fascicularis (S)-propranolol + 2-methylpentanoate
-
 ?
3.1.1.1 (S)-propranolyl 3-methylbutanoate + H2O
-
 Homo sapiens (S)-propranolol + 3-methylbutanoate
-
 ?
3.1.1.1 (S)-propranolyl 3-methylbutanoate + H2O
-
 Macaca fascicularis (S)-propranolol + 3-methylbutanoate
-
 ?
3.1.1.1 (S)-propranolyl hexanoate + H2O
-
 Homo sapiens (S)-propranolol + hexanoate
-
 ?
3.1.1.1 (S)-propranolyl hexanoate + H2O
-
 Macaca fascicularis (S)-propranolol + hexanoate
-
 ?
3.1.1.1 (S)-propranolyl n-valerate + H2O
-
 Homo sapiens (S)-propranolol + pentanoate
-
 ?
3.1.1.1 (S)-propranolyl n-valerate + H2O
-
 Macaca fascicularis (S)-propranolol + pentanoate
-
 ?
3.1.1.1 butyl 4-aminobenzoate + H2O
-
 Homo sapiens 4-aminobenzoate + butanol
-
 ?
3.1.1.1 butyl 4-aminobenzoate + H2O
-
 Macaca fascicularis 4-aminobenzoate + butanol
-
 ?
3.1.1.1 ethyl 4-aminobenzoate + H2O
-
 Homo sapiens 4-aminobenzoate + ethanol
-
 ?
3.1.1.1 ethyl 4-aminobenzoate + H2O
-
 Macaca fascicularis 4-aminobenzoate + ethanol
-
 ?
3.1.1.1 methyl 4-aminobenzoate + H2O
-
 Homo sapiens 4-aminobenzoate + methanol
-
 ?
3.1.1.1 methyl 4-aminobenzoate + H2O
-
 Macaca fascicularis 4-aminobenzoate + methanol
-
 ?
3.1.1.1 additional information enzyme hCE2 prefers the (S)-isomer configuration. Docking simulations of CES2 and propranolol derivatives. Substrate specifcity, overview Homo sapiens ?
-
 ?
3.1.1.1 additional information enzyme hCE2 prefers the (S)-isomer configuration. Docking simulations of CES2 and propranolol derivatives. Substrate specifcity, overview Macaca fascicularis ?
-
 ?
3.1.1.1 propyl 4-aminobenzoate + H2O
-
 Homo sapiens 4-aminobenzoate + propanol
-
 ?
3.1.1.1 propyl 4-aminobenzoate + H2O
-
 Macaca fascicularis 4-aminobenzoate + propanol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 carboxylesterase 2
-
 Homo sapiens
3.1.1.1 carboxylesterase 2
-
 Macaca fascicularis
3.1.1.1 HCE2
-
 Homo sapiens
3.1.1.1 mfCES2v3
-
 Macaca fascicularis