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Literature summary extracted from

  • Vergauwen, B.; Verstraete, K.; Senadheera, D.B.; Dansercoer, A.; Cvitkovitch, D.G.; Guedon, E.; Savvides, S.N.
    Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans (2013), Mol. Microbiol., 89, 288-303 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.4.2.12 membrane
-
 Streptococcus mutans 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1) Streptococcus mutans
-
 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
-
 ?
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1) Streptococcus mutans UA159
-
 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.12 Streptococcus mutans
-
-
-
7.4.2.12 Streptococcus mutans UA159
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
-
 Streptococcus mutans ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
-
 ?
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
-
 Streptococcus mutans UA159 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.12 cystine ABC importer
-
 Streptococcus mutans
7.4.2.12 cystine-specific ABC transporter
-
 Streptococcus mutans
7.4.2.12 tcyABC
-
 Streptococcus mutans
7.4.2.12 TcyB transmembrane permease component Streptococcus mutans
7.4.2.12 TcyC ATPase component Streptococcus mutans

General Information

EC Number General Information Comment Organism
7.4.2.12 physiological function the enzyme is required for growth of Streptococcus mutans on glutathione as the sole source of sulfur Streptococcus mutans