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Literature summary extracted from

  • Manzoni-de-Almeida, D.; Squaiella-Baptistao, C.C.; Lopes, P.H.; van den Berg, C.W.; Tambourgi, D.V.
    Loxosceles venom sphingomyelinase D activates human blood leukocytes Role of the complement system (2018), Mol. Immunol., 94, 45-53 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.41 sphingomyelin + H2O Loxosceles intermedia
-
 ceramide phosphate + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.41 Loxosceles intermedia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.41 venom
-
 Loxosceles intermedia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.41 sphingomyelin + H2O
-
 Loxosceles intermedia ceramide phosphate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.41 SMase D
-
 Loxosceles intermedia

General Information

EC Number General Information Comment Organism
3.1.4.41 physiological function the enzyme is a toxic component of Loxosceles venom that activates human blood leukocytes in a partially complement-dependent manner, which can contribute to the systemic inflammation that follows envenomation by the spider Loxosceles intermedia