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Literature summary extracted from

  • Garcia-Gomez, S.; Reyes, A.; Martinez-Jimenez, M.I.; Chocron, E.S.; Mouron, S.; Terrados, G.; Powell, C.; Salido, E.; Mendez, J.; Holt, I.J.; Blanco, L.
    PrimPol, an archaic primase/polymerase operating in human cells (2013), Mol. Cell, 52, 541-553 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.102 D114A/E116A mutant in two potential metal bindig sites, inactive Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.102 mitochondrion
-
 Homo sapiens 5739
-
2.7.7.102 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.102 Mn2+ presence of Mn2+ is required Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.102 Homo sapiens Q96LW4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.102 M13 ssDNA + n dNTP
-
 Homo sapiens M13 ssDNA/pppdN(pdN)n-1 + (n-1) diphosphate
-
 ?
2.7.7.102 M13 ssDNA + n NTP
-
 Homo sapiens M13 ssDNA/pppN(pN)n-1 + (n-1) diphosphate
-
 ?
2.7.7.102 additional information a template oligonucleotide in which sequence GTCC is flanked by thymine residues is also recognized as substrate, with preferential formation of initiating dinucleotides 5'-A-dG-3' or 5'-dA-dG-3' Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.102 CCDC111
-
 Homo sapiens
2.7.7.102 DNA-directed primase/polymerase protein
-
 Homo sapiens
2.7.7.102 PrimPol
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.7.102 physiological function isoform PRIMPOL gene silencing or ablation impairs mitochondrial DNA replication. PrimPol is proposed to facilitate replication fork progression by acting as a translesion DNA polymerase or as a specific DNA primase reinitiating downstream of lesions that block synthesis during both mitochondrial and nuclear DNA replication Homo sapiens