Any feedback?
Literature summary extracted from
- UgpB, a periplasmic component of the UgpABCE ATP-binding cassette transporter, predominantly follows the Sec translocation pathway (2017), Meta Gene, 13, 129-139 .
No PubMed abstract available
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.6.2.10 | gene ugpB, sequence comparisons and phylogenetic analysis | Escherichia coli |
| 7.6.2.10 | gene ugpB, sequence comparisons and phylogenetic analysis | Mycobacterium tuberculosis |
| 7.6.2.10 | gene ugpB, sequence comparisons and phylogenetic analysis | Thermus thermophilus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.6.2.10 | additional information | Escherichia coli (EcUgpB) follows the Sec pathway for its translocation to the periplasm during its pathogenesis, probable mode of translocation of UgpB proteins in the plasma membrane via the Tat pathway and the Sec pathway, overview. The random clustering of the proteins clearly suggests that, at least, based on sequence homology of proteins no fundamental distinction can be made between Sec- and Tat-specific UgpB proteins. This is indicative of the plausible inference that the targeting of UgpB proteins to Tat or Sec pathway solely depends upon the characteristics of the signal peptide sequence rather than the whole protein | Escherichia coli | - |
- |
| 7.6.2.10 | additional information | Thermus thermophilus (TtUgpB) follows the Sec pathway for its translocation to the periplasm during its pathogenesis, probable mode of translocation of UgpB proteins in the plasma membrane via the Tat pathway and the Sec pathway, overview. The random clustering of the proteins clearly suggests that, at least, based on sequence homology of proteins no fundamental distinction can be made between Sec- and Tat-specific UgpB proteins. This is indicative of the plausible inference that the targeting of UgpB proteins to Tat or Sec pathway solely depends upon the characteristics of the signal peptide sequence rather than the whole protein | Thermus thermophilus | - |
- |
| 7.6.2.10 | additional information | UgpB protein from Mycobacterium tuberculosis (MtUgpB) follows the Tat pathway for its translocation to the periplasm during its pathogenesis, probable mode of translocation of UgpB proteins in the plasma membrane via the Tat pathway and the Sec pathway, overview. The random clustering of the proteins clearly suggests that, at least, based on sequence homology of proteins no fundamental distinction can be made between Sec- and Tat-specific UgpB proteins. This is indicative of the plausible inference that the targeting of UgpB proteins to Tat or Sec pathway solely depends upon the characteristics of the signal peptide sequence rather than the whole protein | Mycobacterium tuberculosis | - |
- |
| 7.6.2.10 | periplasm | - |
Escherichia coli | - |
- |
| 7.6.2.10 | periplasm | - |
Mycobacterium tuberculosis | - |
- |
| 7.6.2.10 | periplasm | - |
Thermus thermophilus | - |
- |
| 7.6.2.10 | plasma membrane | - |
Escherichia coli | 5886 | - |
| 7.6.2.10 | plasma membrane | - |
Mycobacterium tuberculosis | 5886 | - |
| 7.6.2.10 | plasma membrane | - |
Thermus thermophilus | 5886 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.10 | Mg2+ | required | Escherichia coli |  |
| 7.6.2.10 | Mg2+ | required | Mycobacterium tuberculosis | |
| 7.6.2.10 | Mg2+ | required | Thermus thermophilus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | Escherichia coli | - |
ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | Mycobacterium tuberculosis | - |
ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | Thermus thermophilus | - |
ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | Thermus thermophilus DSM 579 | - |
ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | Mycobacterium tuberculosis ATCC 25177 | - |
ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | Thermus thermophilus ATCC 27634 | - |
ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.6.2.10 | Escherichia coli | P0AG80 | - |
- |
| 7.6.2.10 | Mycobacterium tuberculosis | A5U6I5 | - |
- |
| 7.6.2.10 | Mycobacterium tuberculosis ATCC 25177 | A5U6I5 | - |
- |
| 7.6.2.10 | Thermus thermophilus | Q5SLB4 | - |
- |
| 7.6.2.10 | Thermus thermophilus ATCC 27634 | Q5SLB4 | - |
- |
| 7.6.2.10 | Thermus thermophilus DSM 579 | Q5SLB4 | - |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 7.6.2.10 | additional information | UgpB proteins contain a conserved signal peptidase cleavage site irrespective of their translocation pathway | Escherichia coli |
| 7.6.2.10 | additional information | UgpB proteins contain a conserved signal peptidase cleavage site irrespective of their translocation pathway | Mycobacterium tuberculosis |
| 7.6.2.10 | additional information | UgpB proteins contain a conserved signal peptidase cleavage site irrespective of their translocation pathway | Thermus thermophilus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | - |
Escherichia coli | ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | - |
Mycobacterium tuberculosis | ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | - |
Thermus thermophilus | ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | - |
Thermus thermophilus DSM 579 | ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | - |
Mycobacterium tuberculosis ATCC 25177 | ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | ATP + H2O + sn-glycerol 3-phosphate-[glycerol 3-phosphate-binding protein][side 1] | - |
Thermus thermophilus ATCC 27634 | ADP + phosphate + sn-glycerol 3-phosphate[side 2] + [glycerol 3-phosphate-binding protein][side 1] | - |
? | |
| 7.6.2.10 | additional information | the Thermus thermophilus UgpB also transports glycerophosphocholine | Thermus thermophilus | ? | - |
? | |
| 7.6.2.10 | additional information | the Thermus thermophilus UgpB also transports glycerophosphocholine | Thermus thermophilus DSM 579 | ? | - |
? | |
| 7.6.2.10 | additional information | the Thermus thermophilus UgpB also transports glycerophosphocholine | Thermus thermophilus ATCC 27634 | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.6.2.10 | ugpB | - |
Escherichia coli |
| 7.6.2.10 | ugpB | - |
Mycobacterium tuberculosis |
| 7.6.2.10 | ugpB | - |
Thermus thermophilus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.10 | ATP | - |
Escherichia coli | |
| 7.6.2.10 | ATP | - |
Mycobacterium tuberculosis | |
| 7.6.2.10 | ATP | - |
Thermus thermophilus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.6.2.10 | evolution | conservation of the signature residues of UgpB proteins, Sec- and Tat-specific signal peptides vary in their length because of different properties associated with them, Sec-predicted UgpB proteins contain a shorter signal peptide compared to Tat-specific, overview | Mycobacterium tuberculosis |
| 7.6.2.10 | evolution | conservation of the signature residues of UgpB proteins, Sec- and Tat-specific signal peptides vary in their length because of different properties associated with them, Sec-predicted UgpB proteins contain a shorter signal peptide compared to Tat-specific, overview. The majority of UgpB proteins have Sec-specific tripartite structure in their signal peptide. Sec-predicted UgpB proteins contain highly hydrophobic h-region of the tripartite structure | Escherichia coli |
| 7.6.2.10 | evolution | conservation of the signature residues of UgpB proteins, Sec- and Tat-specific signal peptides vary in their length because of different properties associated with them, Sec-predicted UgpB proteins contain a shorter signal peptide compared to Tat-specific, overview. The majority of UgpB proteins have Sec-specific tripartite structure in their signal peptide. Sec-predicted UgpB proteins contain highly hydrophobic h-region of the tripartite structure | Thermus thermophilus |
| 7.6.2.10 | physiological function | periplasmic UgpB protein is a periplasmic solute (or substrate) binding protein of UgpABCE ATP-binding cassette (ABC) transporter, which mediates the sequestration of either sn-glycerol-3-phosphate (G3P) or glycerophosphocholine (GPC) molecules in the periplasmic space. Mycobacterium tuberculosis UgpB protein is crucial for its optimal growth. UgpB protein from Mycobacterium tuberculosis (MtUgpB) follows the Tat pathway for its translocation to the periplasm during its pathogenesis, probable mode of translocation of UgpB proteins in the plasma membrane via the Tat pathway and the Sec pathway, overview | Mycobacterium tuberculosis |
| 7.6.2.10 | physiological function | periplasmic UgpB protein is a periplasmic solute (or substrate) binding protein of UgpABCE ATP-binding cassette (ABC) transporter, which mediates the sequestration of either sn-glycerol-3-phosphate (G3P) or glycerophosphocholine (GPC) molecules in the periplasmic space. UgpB protein from Escherichia coli (EcUgpB) follows the Sec pathway for its translocation to the periplasm during its pathogenesis, probable mode of translocation of UgpB proteins in the plasma membrane via the Tat pathway or the Sec pathway, overview | Escherichia coli |
| 7.6.2.10 | physiological function | periplasmic UgpB protein is a periplasmic solute (or substrate) binding protein of UgpABCE ATP-binding cassette (ABC) transporter, which mediates the sequestration of either sn-glycerol-3-phosphate (G3P) or glycerophosphocholine (GPC) molecules in the periplasmic space. UgpB protein from Thermus thermophilus (TtUgpB) follows the Sec pathway for its translocation to the periplasm during its pathogenesis, probable mode of translocation of UgpB proteins in the plasma membrane via the Tat pathway and the Sec pathway, overview | Thermus thermophilus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
