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Literature summary extracted from

  • Mahat, B.; Chasse, E.; Mauger, J.F.; Imbeault, P.
    Effects of acute hypoxia on human adipose tissue lipoprotein lipase activity and lipolysis (2016), J. Transl. Med., 14, 212 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.34 triacylglycerol + H2O Homo sapiens
-
 diacylglycerol + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.34 Homo sapiens P06858
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.34 adipose tissue
-
 Homo sapiens
-
3.1.1.34 preadipocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.34 triacylglycerol + H2O
-
 Homo sapiens diacylglycerol + a carboxylate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.34 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.34 8
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.34 malfunction acute hypoxia strongly inhibits lipoprotein lipase activity in differentiated human preadipocytes and increases non-esterified fatty acid release, adversely affecting postprandial lipemia. In differentiated preadipocytes, acute hypoxia induces a 6fold reduction in lipoprotein lipase activity. Acute intermittent hypoxia increases circulating plasma non-esterified fatty acid in young healthy men, but does not seem to affect postprandial triglyceride levels, nor subcutaneous abdominal adipose tissue lipoprotein lipase activity and adipocyte lipolysis. The reduction in adipose tissue LPL activity appears to be explained by the upregulation of an important posttranslational repressor of LPL, angiopoietin-like protein 4 (ANGPTL4) Homo sapiens
3.1.1.34 physiological function adipose tissue regulates postprandial lipid metabolism by storing dietary fat through lipoprotein lipase-mediated hydrolysis of exogenous triglycerides, and by inhibiting delivery of endogenous non-esterified fatty acid to nonadipose tissues. In humans, the rise in postprandial triglyceride levels does not differ between normoxia and intermittent hypoxia. Nonesterified fatty acid levels are higher during intermittent hypoxia session. Intermittent hypoxia does not affect subcutaneous abdominal adipose tissue lipoprotein lipase activity. No differences are observed in lipolytic responses of isolated subcutaneous abdominal adipocytes between normoxia and intermittent hypoxia sessions Homo sapiens