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Literature summary extracted from
- Expression of carboxylesterase isozymes and their role in the behavior of a fexofenadine prodrug in rat skin (2016), J. Pharm. Sci., 105, 714-721 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.1 | bis-4-nitrophenyl phosphate | BNPP, a specific inhibitor of CES, inhibits the hydrolysis of ethyl-FXD in rat skin S9 fraction in a dose-dependent manner, 99% inhibition at 1 mM BNPP | Rattus norvegicus |  |
| 3.1.1.1 | bis-p-nitrophenyl phosphate | BNPP, a specific inhibitor of CES, inhibits the hydrolysis of ethyl-FXD in rat skin S9 fraction in a dose-dependent manner, 99% inhibition at 1 mM BNPP | Rattus norvegicus | |
| 3.1.1.1 | additional information | ethopropazine, a specific inhibitor of butyrylcholinesterase (EC 3.1.1.8), shows no inhibitory effect; ethopropazine, a specific inhibitor of butyrylcholinesterase (EC 3.1.1.8), shows no inhibitory effect | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.1 | Rattus norvegicus | O35535 | - |
- |
| 3.1.1.1 | Rattus norvegicus | O70177 | - |
- |
| 3.1.1.1 | Rattus norvegicus Wistar | O35535 | - |
- |
| 3.1.1.1 | Rattus norvegicus Wistar | O70177 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.1 | skin | of 8-week-old rats | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.1 | ethyl fexofenadine + H2O | - |
Rattus norvegicus | fexofenadine + ethanol | - |
? | |
| 3.1.1.1 | ethyl fexofenadine + H2O | - |
Rattus norvegicus Wistar | fexofenadine + ethanol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.1 | CES | - |
Rattus norvegicus |
| 3.1.1.1 | CES1 | - |
Rattus norvegicus |
| 3.1.1.1 | CES2 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.1 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.1 | 7.4 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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