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Literature summary extracted from

  • Moffat, C.; Bhatia, L.; Nguyen, T.; Lynch, P.; Wang, M.; Wang, D.; Ilkayeva, O.; Han, X.; Hirschey, M.; Claypool, S.; Seifert, E.
    Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver (2015), J. Lipid Res., 55, 2458-2470 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.2 0.0033
-
 palmitoyl-CoA at pH 7.6 and 37°C Mus musculus
3.1.2.2 0.0033
-
 myristoyl-CoA at pH 7.6 and 37°C Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 acyl-CoA + H2O Mus musculus
-
 CoA + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Mus musculus Q9QYR9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 hepatocyte
-
 Mus musculus
-
3.1.2.2 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
3.1.2.2 linoleoyl-CoA + H2O
-
 Mus musculus CoA + linoleate
-
 ?
3.1.2.2 additional information no activity with octanoyl-CoA Mus musculus ?
-
 ?
3.1.2.2 myristoyl-CoA + H2O
-
 Mus musculus CoA + myristate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Mus musculus CoA + oleate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Mus musculus CoA + palmitate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.2 ACOT2
-
 Mus musculus
3.1.2.2 acyl-CoA thioesterase-2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.2.2 metabolism the enzyme enhances fatty acid oxidation, possibly by mitigating the accumulation of fatty acid oxidation intermediates within the mitochondrial matrix. The enzyme increases proton leak in liver mitochondria Mus musculus