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Literature summary extracted from

  • Shen, S.; Chen, W.; Dong, L.; Yang, Q.; Lu, H.; Zhang, J.
    Design and synthesis of naphthalimide group-bearing thioglycosides as novel beta-N-acetylhexosaminidases inhibitors (2018), J. Enzyme Inhib. Med. Chem., 33, 445-452 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.52 expressed in Pichia pastoris GS115 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.52 2,2''-[azanediyldi(ethane-2,1-diyl)]di(1H-benzo[de]isoquinoline-1,3(2H)-dione) M-31850 Homo sapiens
3.2.1.52 2-(2-([(4-methoxyphenyl)methyl]amino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-(2-([(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethyl]-1H-benzo[de]isoquinoline-isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[2-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[2-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[2-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[2-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[3-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[3-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[3-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[3-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[4-[(2-acetamido-beta-D-glucopyranosyl)thio]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[4-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethylamino]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[4-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propylamino]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[4-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentylamino]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[4-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexylamino]butyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 2-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Homo sapiens
3.2.1.52 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
-
 Homo sapiens
3.2.1.52 iminocyclitol
-
 Homo sapiens
3.2.1.52 NAG-thiazoline
-
 Homo sapiens
3.2.1.52 nagstatin
-
 Homo sapiens
3.2.1.52 naphthalimide
-
 Homo sapiens
3.2.1.52 PUGNAc
-
 Homo sapiens
3.2.1.52 pyrimethamine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.52 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.52 His-Trap column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.52 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
-
 Homo sapiens 4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.52 Hex
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.52 0.00091
-
 2-[2-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexylamino]ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione at pH 4.0 and 30°C Homo sapiens
3.2.1.52 0.03042
-
 2-[3-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethylamino]propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione at pH 4.0 and 30°C Homo sapiens