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Literature summary extracted from

  • Chen, D.; Yang, C.; Liu, S.; Hang, W.; Wang, X.; Chen, J.; Shi, A.
    SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity (2018), J. Cell Biol., 217, 2121-2139 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.36 endosome
-
 Caenorhabditis elegans 5768
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.36 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Caenorhabditis elegans
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.36 Caenorhabditis elegans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.36 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Caenorhabditis elegans 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.36 ? x * 96000, GST-tagged enzyme, SDS-PAGE Caenorhabditis elegans

Synonyms

EC Number Synonyms Comment Organism
3.1.3.36 phosphoinositide phosphatase
-
 Caenorhabditis elegans
3.1.3.36 SAC-1
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
3.1.3.36 malfunction enzyme depletion exclusively impairs apical secretory transport in intestinal epithelia. Enzyme loss leads to increased phosphatidylinositol 4,5-bisphosphate levels and overaccumulation of actin structures as well as intracellular accumulation of ARF-6 and UNC-16 Caenorhabditis elegans
3.1.3.36 metabolism the interaction of the enzyme with ARF-6 curbs ARF-6 activity by limiting the access of ARF-6(GDP) to its guanine nucleotide exchange factor, BRIS-1 Caenorhabditis elegans