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Literature summary extracted from

  • Nakazawa, N.; Arakawa, O.; Ebe, M.; Yanagida, M.
    Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast (2019), J. Biol. Chem., 294, 3772-3782 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
5.6.2.2 S1363A/S1364A the non-phosphorylatable alanine double mutant maintains decatenation activity but has lost much of its ability to hydrolyze ATP as compared to the wild type enzyme Schizosaccharomyces pombe
5.6.2.2 S1363E/S1364E phosphomimetic double mutant Schizosaccharomyces pombe

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 ICRF-193 i.e., meso-4,4-(2,3-butanediyl)-bis (2,6-piperazinedione) Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + topoisomerase II Schizosaccharomyces pombe
-
 ADP + phosphorylated topoisomerase II
-
 ?
2.7.11.1 ATP + topoisomerase II Schizosaccharomyces pombe 972
-
 ADP + phosphorylated topoisomerase II
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Schizosaccharomyces pombe P40231
-
-
2.7.11.1 Schizosaccharomyces pombe 972 P40231
-
-
5.6.2.2 Schizosaccharomyces pombe
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
5.6.2.2 phosphoprotein casein kinase II phosphorylates the C-terminal residues Ser-1363 and Ser-1364 Schizosaccharomyces pombe

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + topoisomerase II
-
 Schizosaccharomyces pombe ADP + phosphorylated topoisomerase II
-
 ?
2.7.11.1 ATP + topoisomerase II Ser1363 and Ser1364 in topoisomerase II are targeted by Cka1/CKII kinase Schizosaccharomyces pombe ADP + phosphorylated topoisomerase II
-
 ?
2.7.11.1 ATP + topoisomerase II
-
 Schizosaccharomyces pombe 972 ADP + phosphorylated topoisomerase II
-
 ?
2.7.11.1 ATP + topoisomerase II Ser1363 and Ser1364 in topoisomerase II are targeted by Cka1/CKII kinase Schizosaccharomyces pombe 972 ADP + phosphorylated topoisomerase II
-
 ?
5.6.2.2 ATP + kinetoplast DNA
-
 Schizosaccharomyces pombe ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 casein kinase II
-
 Schizosaccharomyces pombe
2.7.11.1 CKII kinase
-
 Schizosaccharomyces pombe
5.6.2.2 DNA topoisomerase II
-
 Schizosaccharomyces pombe
5.6.2.2 Top2
-
 Schizosaccharomyces pombe
5.6.2.2 topo II
-
 Schizosaccharomyces pombe

General Information

EC Number General Information Comment Organism
2.7.11.1 drug target possible benefits of applying CKII inhibitors in combination with topo II catalytic inhibitors for effective prevention of mitotic chromosome segregation in tumor cells Schizosaccharomyces pombe
2.7.11.1 evolution CKII-mediated phosphorylation of the topo II C-terminal domain appears to be evolutionarily conserved, including in humans Schizosaccharomyces pombe
2.7.11.1 metabolism attenuation of CKII-controlled topoisomerase II phosphorylation along with catalytic topo II inhibition may promote anticancer effects Schizosaccharomyces pombe