Literature summary extracted from

Ehrhardt, A.; Chung, W.J.; Pyle, L.C.; Wang, W.; Nowotarski, K.; Mulvihill, C.M.; Ramjeesingh, M.; Hong, J.; Velu, S.E.; Lewis, H.A.; Atwell, S.; Aller, S.; Bear, C.E.; Lukacs, G.L.; Kirk, K.L.; Sorscher, E.J.
Channel gating regulation by the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loop (2016), J. Biol. Chem., 291, 1854-1865 .

Protein Variants

EC Number	Protein Variants	Comment	Organism
5.6.1.6	F508del	the mutation is associated with cystic fibrosis	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.6.1.6	CL1 peptide	both intrinsic ATPase activity and channel gating are inhibited severely by CL1 peptide	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.6.1.6	ATP + H2O + closed Cl- channel	Homo sapiens	-	ADP + phosphate + open Cl- channel	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.6.1.6	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
5.6.1.6	HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.6.1.6	ATP + H2O + closed Cl- channel	-	Homo sapiens	ADP + phosphate + open Cl- channel	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
5.6.1.6	CFTR	-	Homo sapiens
5.6.1.6	cystic fibrosis transmembrane conductance regulator	-	Homo sapiens

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Release 2023.1 (January 2023)