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Literature summary extracted from

  • Chonoles Imlay, K.R.; Korshunov, S.; Imlay, J.A.
    Physiological roles and adverse effects of the two cystine importers of Escherichia coli (2015), J. Bacteriol., 197, 3629-3644 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.4.2.12 selenocystine competitively blocks cystine import by enzyme form YdjN Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.12 ATP + H2O + D-cystine-[cystine-binding protein](side 1) Escherichia coli
-
 ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein](side 1) Escherichia coli
-
 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.12 Escherichia coli
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.4.2.12 culture condition:D-cystine-grown cell
-
 Escherichia coli
-
7.4.2.12 culture condition:L-cystine-grown cell
-
 Escherichia coli
-
7.4.2.12 culture condition:sulfate-grown cell
-
 Escherichia coli
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.12 ATP + H2O + D-cystine-[cystine-binding protein](side 1)
-
 Escherichia coli ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?
7.4.2.12 ATP + H2O + diaminopimelate-[diaminopimelate-binding protein](side 1)
-
 Escherichia coli ADP + phosphate + diaminopimelate(side 2) + [diaminopimelate-binding protein](side 1)
-
 ?
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein](side 1)
-
 Escherichia coli ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.12 cystine importer
-
 Escherichia coli
7.4.2.12 FliY-YecSC
-
 Escherichia coli
7.4.2.12 tcyJLN
-
 Escherichia coli
7.4.2.12 tcyP
-
 Escherichia coli
7.4.2.12 YdjN
-
 Escherichia coli

Expression

EC Number Organism Comment Expression
7.4.2.12 Escherichia coli the enzyme is strongly induced by the regulon CysB response to sulfur scarcity up

General Information

EC Number General Information Comment Organism
7.4.2.12 metabolism enzyme form FliY-YecSC is essential for import of trace cystine, whereas enzyme form YdjN is the predominant importer when cystine is more abundant. YdjN is responsible for the rapid cystine import and H2O2 sensitivity of Escherichia coli that has been pre-grown in sulfate medium, but the rapid transport and H2O2 sensitivity are absent if cells have been pre-grown in cystine medium Escherichia coli