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Literature summary extracted from

  • Macdonald, I.R.; Maxwell, S.P.; Reid, G.A.; Cash, M.K.; DeBay, D.R.; Darvesh, S.
    Quantification of butyrylcholinesterase activity as a sensitive and specific biomarker of Alzheimers disease (2017), J. Alzheimers Dis., 58, 491-505 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.1.8 diagnostics butyrylcholinesterase activity is a sensitive and specific biomarker of Alzheimers disease (AD), BChE-associated amyloid-beta plaques has the potential as an improved AD biomarker. The predictive value of BChE as a biomarker for AD facilitates timely disease diagnosis and management Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.8 butyrylcholine + H2O Homo sapiens
-
 choline + butyrate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 brain from postmortem brain tissues with Alzheimer's disease, amyloid-beta plaques, cognitively normal without plaques, and other common dementias including corticobasal degeneration, frontotemporal dementia with tau, dementia with Lewy bodies, and vascular dementia. Orbitofrontal cortex, entorhinal cortex, amygdala, and hippocampal formation. Amyloid-beta and BChE-associated pathologies are greater in Alzheimer's disease, particularly in the orbitofrontal cortex. In Alzheimer's disease, the neocortex is one of the earliest areas for accumulation of amyloid-beta pathology Homo sapiens
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3.1.1.8 additional information no association of BChE to pathology in other neurodegenerative disorders, cases from corticobasal degeneration (CBD), one frontotemporal dementia with tau (FTD-tau), one dementia with Lewy bodies (DLB), and one vascular dementia (VaD) are examined Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 butyrylcholine + H2O
-
 Homo sapiens choline + butyrate
-
 ?
3.1.1.8 butyrylthiocholine + H2O histochemic activity detection Homo sapiens thiocholine + butyrate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
 Homo sapiens
3.1.1.8 butyrylcholinesterase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.8 6.8
-
 assay at Homo sapiens