EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.4.59 | D134a/H135A/H136A | mutation in DHH domain, complete loss of catalytic activity | Mycolicibacterium smegmatis |
3.1.4.59 | G313A/G314A/G315A/H316A | mutation in DHHA1 domain, mutasnt displays residual activity | Mycolicibacterium smegmatis |
3.1.4.60 | D134a/H135A/H136A | mutation in DHH domain, complete loss of catalytic activity | Mycolicibacterium smegmatis |
3.1.4.60 | G313A/G314A/G315A/H316A | mutation in DHHA1 domain, mutant displays residual activity | Mycolicibacterium smegmatis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.4.59 | 0.0068 | - |
cyclic di-3',5'-adenylate | pH 7.8, 37°C | Mycolicibacterium smegmatis | |
3.1.4.59 | 0.0809 | - |
cyclic di-3',5'-guanylate | pH 7.8, 37°C | Mycolicibacterium smegmatis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.59 | Co2+ | Pde is strictly dependent on Co2+, Mn2+, Mg2+ or Fe2+, with maximum activity with Mn2+ as a cofactor | Mycolicibacterium smegmatis | |
3.1.4.59 | Fe2+ | Pde is strictly dependent on Co2+, Mn2+, Mg2+ or Fe2+, with maximum activity with Mn2+ as a cofactor | Mycolicibacterium smegmatis | |
3.1.4.59 | Mg2+ | Pde is strictly dependent on Co2+, Mn2+, Mg2+ or Fe2+, with maximum activity with Mn2+ as a cofactor | Mycolicibacterium smegmatis | |
3.1.4.59 | Mn2+ | Pde is strictly dependent on Co2+, Mn2+, Mg2+ or Fe2+, with maximum activity with Mn2+ as a cofactor | Mycolicibacterium smegmatis | |
3.1.4.60 | Co2+ | Pde is strictly dependent on Co2+, Mn2+, Mg2+ or Fe2+, with maximum activity with Mn2+ as a cofactor | Mycolicibacterium smegmatis | |
3.1.4.60 | Fe2+ | Pde is strictly dependent on Co2+, Mn2+, Mg2+ or Fe2+, with maximum activity with Mn2+ as a cofactor | Mycolicibacterium smegmatis | |
3.1.4.60 | Mg2+ | Pde is strictly dependent on Co2+, Mn2+, Mg2+ or Fe2+, with maximum activity with Mn2+ as a cofactor | Mycolicibacterium smegmatis | |
3.1.4.60 | Mn2+ | Pde is strictly dependent on Co2+, Mn2+, Mg2+ or Fe2+, with maximum activity with Mn2+ as a cofactor | Mycolicibacterium smegmatis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.59 | cyclic di-3',5'-adenylate + H2O | Mycolicibacterium smegmatis | - |
5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
3.1.4.59 | cyclic di-3',5'-adenylate + H2O | Mycolicibacterium smegmatis ATCC 700084 | - |
5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
3.1.4.60 | 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O | Mycolicibacterium smegmatis | - |
2 AMP | - |
? | |
3.1.4.60 | 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O | Mycolicibacterium smegmatis ATCC 700084 | - |
2 AMP | - |
? | |
3.1.4.60 | cyclic di-3',5'-adenylate + H2O | Mycolicibacterium smegmatis | - |
5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
3.1.4.60 | cyclic di-3',5'-adenylate + H2O | Mycolicibacterium smegmatis ATCC 700084 | - |
5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.59 | Mycolicibacterium smegmatis | A0QVM9 | protein contains a DHH-DHHAI domain | - |
3.1.4.59 | Mycolicibacterium smegmatis ATCC 700084 | A0QVM9 | protein contains a DHH-DHHAI domain | - |
3.1.4.60 | Mycolicibacterium smegmatis | A0QVM9 | protein contains a DHH-DHHAI domain | - |
3.1.4.60 | Mycolicibacterium smegmatis ATCC 700084 | A0QVM9 | protein contains a DHH-DHHAI domain | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.59 | cyclic di-3',5'-adenylate + H2O | - |
Mycolicibacterium smegmatis | 5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
3.1.4.59 | cyclic di-3',5'-adenylate + H2O | - |
Mycolicibacterium smegmatis ATCC 700084 | 5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
3.1.4.59 | cyclic di-3',5'-guanylate + H2O | - |
Mycolicibacterium smegmatis | 5'-phosphoguanylyl-(3'->5')guanosine | - |
? | |
3.1.4.59 | cyclic di-3',5'-guanylate + H2O | - |
Mycolicibacterium smegmatis ATCC 700084 | 5'-phosphoguanylyl-(3'->5')guanosine | - |
? | |
3.1.4.59 | additional information | Pde is capable of converting c-di-AMP to pApA, i.e. 5'-O-phosphonoadenylyl-(3'->5')-adenosine and AMP, and hydrolyzing pApA to AMP | Mycolicibacterium smegmatis | ? | - |
? | |
3.1.4.59 | additional information | Pde is capable of converting c-di-AMP to pApA, i.e. 5'-O-phosphonoadenylyl-(3'->5')-adenosine and AMP, and hydrolyzing pApA to AMP | Mycolicibacterium smegmatis ATCC 700084 | ? | - |
? | |
3.1.4.60 | 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O | - |
Mycolicibacterium smegmatis | 2 AMP | - |
? | |
3.1.4.60 | 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O | - |
Mycolicibacterium smegmatis ATCC 700084 | 2 AMP | - |
? | |
3.1.4.60 | cyclic di-3',5'-adenylate + H2O | - |
Mycolicibacterium smegmatis | 5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
3.1.4.60 | cyclic di-3',5'-adenylate + H2O | - |
Mycolicibacterium smegmatis ATCC 700084 | 5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.59 | MSMEG_2630 | - |
Mycolicibacterium smegmatis |
3.1.4.59 | PDE | - |
Mycolicibacterium smegmatis |
3.1.4.60 | MSMEG_2630 | - |
Mycolicibacterium smegmatis |
3.1.4.60 | PDE | - |
Mycolicibacterium smegmatis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.1.4.59 | 37 | - |
assay at | Mycolicibacterium smegmatis |
3.1.4.59 | 37 | 50 | - |
Mycolicibacterium smegmatis |
3.1.4.60 | 37 | - |
assay at | Mycolicibacterium smegmatis |
3.1.4.60 | 37 | 50 | - |
Mycolicibacterium smegmatis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.4.59 | 0.03 | - |
cyclic di-3',5'-guanylate | pH 7.8, 37°C | Mycolicibacterium smegmatis | |
3.1.4.59 | 0.52 | - |
cyclic di-3',5'-adenylate | pH 7.8, 37°C | Mycolicibacterium smegmatis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.4.59 | 7.5 | - |
- |
Mycolicibacterium smegmatis |
3.1.4.60 | 7.5 | - |
- |
Mycolicibacterium smegmatis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.4.59 | physiological function | deficiency of Pde significantly enhances intracellular C12-C20 fatty acid accumulation. Superfluous c-di-AMP in Mycobacterium smegmatis may lead to abnormal colonial morphology | Mycolicibacterium smegmatis |
3.1.4.60 | physiological function | deficiency of Pde significantly enhances intracellular C12-C20 fatty acid accumulation. Superfluous c-di-AMP in Mycobacterium smegmatis may lead to abnormal colonial morphology | Mycolicibacterium smegmatis |