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Literature summary extracted from

  • van Veen, M.; Mans, L.A.; Matas-Rico, E.; van Pelt, J.; Perrakis, A.; Moolenaar, W.H.; Haramis, A.G.
    Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish (2018), Int. J. Biochem. Cell Biol., 94, 71-78 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.11 plasma membrane zebrafish Gdpd5 orthologues localize to the plasma membrane where they show catalytic activity against GPI-anchored glypican-6 Danio rerio 5886
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Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Danio rerio E9QG52 isoform Gdpd5a
-
3.1.4.11 Danio rerio X1WHY1 isoform Gdpd5b
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3.1.4.11 Homo sapiens Q8WTR4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 GDE2
-
 Homo sapiens
3.1.4.11 GDE2
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 Danio rerio
3.1.4.11 GDPD5
-
 Danio rerio
3.1.4.11 glycerophosphodiester phosphodiesterase domain-containing 5a
-
 Danio rerio
3.1.4.11 glycerophosphodiester phosphodiesterase domain-containing 5b
-
 Danio rerio

General Information

EC Number General Information Comment Organism
3.1.4.11 physiological function knockdown of both isoforms Gdpd5a and Gdpd5b in zebrafish embryos leads to developmental defects, particularly impaired motility and reduced pancreas differentiation. Exogenous expression of human GDE2 similarly leads to developmental defects. Expression of human GDE2 restores insulin expression in Gdpd5a-depleted zebrafish embryos Homo sapiens
3.1.4.11 physiological function knockdown of both isoforms Gdpd5a and Gdpd5b in zebrafish embryos leads to developmental defects, particularly impaired motility and reduced pancreas differentiation. Exogenous expression of human GDE2 similarly leads to developmental defects. Expression of human GDE2 restores insulin expression in Gdpd5a-depleted zebrafish embryos Danio rerio