Literature summary extracted from

Castellazzi, M.; Trentini, A.; Romani, A.; Valacchi, G.; Bellini, T.; Bonaccorsi, G.; Fainardi, E.; Cavicchio, C.; Passaro, A.; Zuliani, G.; Cervellati, C.
Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases (2016), Int. J. Biochem. Cell Biol., 81, 356-363 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.2	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.1.2	blood serum	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.2	phenyl acetate + H2O	-	Homo sapiens	phenol + acetate	-	?

Expression

EC Number	Organism	Comment	Expression
3.1.1.2	Homo sapiens	enzyme levels are significantly lower in patients affected by mild cognitive impairment, vascular dementia, late onset Alzheimer's disease, late onset Alzheimer's disease-vascular dementia mixed dementia as well as those with multiple sclerosis as compared to healthy controls	down

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Release 2023.1 (January 2023)