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Literature summary extracted from

  • Gellings, P.S.; McGee, D.J.
    Arcanobacterium haemolyticum utilizes both phospholipase D and arcanolysin to mediate its uptake into non-phagocytic cells (2019), Infect. Immun., 87, e00832-18 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.41 expressed in Escherichia coli DH5alpha cells Arcanobacterium haemolyticum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.41 sphingomyelin + H2O Arcanobacterium haemolyticum
-
 ceramide phosphate + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.41 Arcanobacterium haemolyticum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.41 Ni-NTA resin column chromatography Arcanobacterium haemolyticum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.41 sphingomyelin + H2O
-
 Arcanobacterium haemolyticum ceramide phosphate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.41 phospholipase D
-
 Arcanobacterium haemolyticum
3.1.4.41 PLD
-
 Arcanobacterium haemolyticum
3.1.4.41 sphingomyelin-specific phospholipase D
-
 Arcanobacterium haemolyticum

General Information

EC Number General Information Comment Organism
3.1.4.41 physiological function Arcanobacterium haemolyticum utilizes phospholipase D to mediate its uptake into non-phagocytic cell. The sphingomyelinase activity of phospholipase D is necessary to increase bacterial adherence to Detroit 562 cells Arcanobacterium haemolyticum