EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.34 | gene Lpl, real-time PCR enzyme expression analysis | Homo sapiens |
3.1.1.34 | gene Lpl, real-time PCR enzyme expression analysis | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.34 | triacylglycerol + H2O | Homo sapiens | - |
diacylglycerol + a carboxylate | - |
? | |
3.1.1.34 | triacylglycerol + H2O | Mus musculus | - |
diacylglycerol + a carboxylate | - |
? | |
3.1.1.34 | triacylglycerol + H2O | Mus musculus C57BL/6J | - |
diacylglycerol + a carboxylate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.34 | Homo sapiens | P06858 | - |
- |
3.1.1.34 | Mus musculus | P11152 | - |
- |
3.1.1.34 | Mus musculus C57BL/6J | P11152 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.34 | brain | - |
Homo sapiens | - |
3.1.1.34 | brain | - |
Mus musculus | - |
3.1.1.34 | BV-2 cell | - |
Mus musculus | - |
3.1.1.34 | central nervous system | - |
Homo sapiens | - |
3.1.1.34 | central nervous system | - |
Mus musculus | - |
3.1.1.34 | macrophage | - |
Homo sapiens | - |
3.1.1.34 | macrophage | - |
Mus musculus | - |
3.1.1.34 | microglial cell line | - |
Homo sapiens | - |
3.1.1.34 | microglial cell line | - |
Mus musculus | - |
3.1.1.34 | Schwann cell | - |
Homo sapiens | - |
3.1.1.34 | Schwann cell | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.34 | additional information | enzymatic activity of cell-surface heparin-released LPL is measured using a phospholipid (PL)/3H-triolein substrate with human serum as a source of ApoC2 | Mus musculus | ? | - |
? | |
3.1.1.34 | additional information | tic activity of cell-surface heparin-released LPL is measured using a phospholipid (PL)/3H-triolein substrate with human serum as a source of ApoC2 | Homo sapiens | ? | - |
? | |
3.1.1.34 | additional information | enzymatic activity of cell-surface heparin-released LPL is measured using a phospholipid (PL)/3H-triolein substrate with human serum as a source of ApoC2 | Mus musculus C57BL/6J | ? | - |
? | |
3.1.1.34 | triacylglycerol + H2O | - |
Homo sapiens | diacylglycerol + a carboxylate | - |
? | |
3.1.1.34 | triacylglycerol + H2O | - |
Mus musculus | diacylglycerol + a carboxylate | - |
? | |
3.1.1.34 | triacylglycerol + H2O | - |
Mus musculus C57BL/6J | diacylglycerol + a carboxylate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.34 | LPL | - |
Homo sapiens |
3.1.1.34 | LPL | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.1.34 | malfunction | lipoprotein lipase (LPL) is increased during the onset of remyelination, which is associated with an anti-inflammatory reparative microglial phenotype, and may facilitate the uptake of myelin-derived lipids in the CNS | Homo sapiens |
3.1.1.34 | malfunction | lipoprotein lipase (LPL)-deficient cells show dramatically reduced expression of anti-inflammatory markers, YM1, and arginase 1 and increased expression of pro-inflammatory markers, such as iNOS compared to wild-type cells. LPL is increased during the onset of remyelination, which is associated with an anti-inflammatory reparative microglial phenotype, and may facilitate the uptake of myelin-derived lipids in the CNS | Mus musculus |
3.1.1.34 | physiological function | lipoprotein lipase is a feature of alternatively-activated microglia and may facilitate lipid uptake in the CNS during demyelination. Lipoprotein lipase is involved in microglial lipid uptake. Lipoprotein lipase (LPL) is the rate-limiting enzyme in the hydrolysis of triglyceride-rich lipoproteins and is increased in Schwann cells and macrophages following nerve crush injury in the peripheral nervous system (PNS), suggesting that LPL may help scavenge myelin-derived lipids. Role of LPL in microglia, overview | Homo sapiens |
3.1.1.34 | physiological function | lipoprotein lipase is a feature of alternatively-activated microglia, reparative microglia cells, and may facilitate lipid uptake in the CNS during demyelination. Lipoprotein lipase is involved in microglial lipid uptake. LPL may support repair through the clearance of myelin-derived lipids. Lipoprotein lipase (LPL) is the rate-limiting enzyme in the hydrolysis of triglyceride-rich lipoproteins and is increased in Schwann cells and macrophages following nerve crush injury in the peripheral nervous system (PNS), suggesting that LPL may help scavenge myelin-derived lipids. Role of LPL in microglia, overview | Mus musculus |