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Literature summary extracted from

  • De Leo, M.; Huallpa, C.G.; Alvarado, B.; Granchi, C.; Poli, G.; De Tommasi, N.; Braca, A.
    New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL) (2018), Fitoterapia, 130, 251-258 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.23 additional information no effect by DTT at 0.1 mM Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 (4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)-methanone
-
 Homo sapiens
3.1.1.23 12-deacetylsplendidin C poor inhibition Homo sapiens
3.1.1.23 2-dehydroxysalvileucanthsin A poor inhibition Homo sapiens
3.1.1.23 eriodictyol
-
 Homo sapiens
3.1.1.23 jewenol A reversible inhibitor, catalytic site binding structure, overview Homo sapiens
3.1.1.23 additional information diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL), NMR structure analysis, molecular docking into the catalytic site of the enzyme, overview. No effect by DTT at 0.1 mM and by galloflavin Homo sapiens
3.1.1.23 oleanolic acid
-
 Homo sapiens
3.1.1.23 pedalitin
-
 Homo sapiens
3.1.1.23 Protocatechualdehyde
-
 Homo sapiens
3.1.1.23 pseudorosmaricin poor inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Homo sapiens Q99685
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 4-nitrophenyl acetate + H2O
-
 Homo sapiens 4-nitrophenol + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MAGL
-
 Homo sapiens
3.1.1.23 monoacylglycerol lipase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.23 7.2
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.23 0.0117
-
 pH 7.2, temperature not specified in the publication Homo sapiens (4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)-methanone
3.1.1.23 0.0468
-
 pH 7.2, temperature not specified in the publication Homo sapiens jewenol A
3.1.1.23 0.2
-
 above, pH 7.2, temperature not specified in the publication Homo sapiens 12-deacetylsplendidin C
3.1.1.23 0.2
-
 above, pH 7.2, temperature not specified in the publication Homo sapiens 2-dehydroxysalvileucanthsin A
3.1.1.23 0.2
-
 above, pH 7.2, temperature not specified in the publication Homo sapiens pseudorosmaricin