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Literature summary extracted from

  • Kim, J.; Senadheera, D.; Levesque, C.; Cvitkovitch, D.
    TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans (2012), FEMS Microbiol. Lett., 328, 114-121 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.4.2.12 DL-cystathionine strongly inhibited by DL-cystathionine Streptococcus mutans
7.4.2.12 L-cysteine moderately inhibited by L-cysteine Streptococcus mutans
7.4.2.12 L-djenkolic acid strongly inhibited by L-djenkolic acid Streptococcus mutans
7.4.2.12 additional information not inhibited by FeSO4, L-arginine, L-glutamine, L-glutamate, L-leucine, and L-methionine Streptococcus mutans
7.4.2.12 S-methyl-L-cysteine moderately inhibited by S-methyl-L-cysteine Streptococcus mutans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein](side 1) Streptococcus mutans
-
 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein](side 1) Streptococcus mutans UA159
-
 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.12 Streptococcus mutans
-
-
-
7.4.2.12 Streptococcus mutans UA159
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein](side 1)
-
 Streptococcus mutans ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?
7.4.2.12 ATP + H2O + L-cystine-[cystine-binding protein](side 1)
-
 Streptococcus mutans UA159 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.12 cystine ABC transporter
-
 Streptococcus mutans
7.4.2.12 TcyABC transporter
-
 Streptococcus mutans
7.4.2.12 TcyB
-
 Streptococcus mutans

Expression

EC Number Organism Comment Expression
7.4.2.12 Streptococcus mutans the transcriptional regulator TcyR negatively regulates the expression of the enzyme down
7.4.2.12 Streptococcus mutans enzyme expression is upregulated under cystine starvation and by the transcriptional activator CysR up