Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Freitas-Mesquita, A.L.; Gomes, M.T.; Vieira, D.P.; Paes-Vieira, L.; Nascimento, M.T.; Lopes, A.H.; Meyer-Fernandes, J.R.
    Inhibitory effects promoted by 5'-nucleotides on the ecto-3'-nucleotidase activity of Leishmania amazonensis (2016), Exp. Parasitol., 169, 111-118 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.6 5'-GMP reversible and uncompetitive inhibition Leishmania amazonensis
3.1.3.6 beta,gamma-methylene-GTP
-
 Leishmania amazonensis
3.1.3.6 GDP
-
 Leishmania amazonensis
3.1.3.6 GTP
-
 Leishmania amazonensis
3.1.3.6 guanosine
-
 Leishmania amazonensis
3.1.3.6 guanosine tetraphosphate
-
 Leishmania amazonensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.6 0.0002
-
 3'-AMP at pH 7.4 and 25°C Leishmania amazonensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.6 a 3'-ribonucleotide + H2O Leishmania amazonensis
-
 a ribonucleoside + phosphate
-
 ?
3.1.3.6 a 3'-ribonucleotide + H2O Leishmania amazonensis MHOM/BR/75/Josefa
-
 a ribonucleoside + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.6 Leishmania amazonensis
-
-
-
3.1.3.6 Leishmania amazonensis MHOM/BR/75/Josefa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.6 promastigote
-
 Leishmania amazonensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.6 3'-AMP + H2O
-
 Leishmania amazonensis adenosine + phosphate
-
 ?
3.1.3.6 3'-AMP + H2O
-
 Leishmania amazonensis MHOM/BR/75/Josefa adenosine + phosphate
-
 ?
3.1.3.6 a 3'-ribonucleotide + H2O
-
 Leishmania amazonensis a ribonucleoside + phosphate
-
 ?
3.1.3.6 a 3'-ribonucleotide + H2O
-
 Leishmania amazonensis MHOM/BR/75/Josefa a ribonucleoside + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.6 3'-NT
-
 Leishmania amazonensis
3.1.3.6 3'-NT/Nu
-
 Leishmania amazonensis
3.1.3.6 ecto-3'-nucleotidase
-
 Leishmania amazonensis
3.1.3.6 ecto-3'-nucleotidase/nuclease
-
 Leishmania amazonensis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.6 0.00371
-
 GDP at pH 7.4 and 25°C Leishmania amazonensis
3.1.3.6 0.00479
-
 5'-GMP at pH 7.4 and 25°C Leishmania amazonensis
3.1.3.6 0.00503
-
 GTP at pH 7.4 and 25°C Leishmania amazonensis
3.1.3.6 0.01732
-
 beta,gamma-methylene-GTP at pH 7.4 and 25°C Leishmania amazonensis
3.1.3.6 0.03229
-
 guanosine at pH 7.4 and 25°C Leishmania amazonensis
3.1.3.6 0.05663
-
 guanosine tetraphosphate at pH 7.4 and 25°C Leishmania amazonensis