BRENDA - Enzyme Database

A putative 3-hydroxyisobutyryl-CoA hydrolase is required for efficient symbiotic nitrogen fixation in Sinorhizobium meliloti and Sinorhizobium fredii NGR234

Zamani, M.; diCenzo, G.C.; Milunovic, B.; Finan, T.M.; Environ. Microbiol. 19, 218-236 (2017)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
Sinorhizobium meliloti
-
CoA + (S)-3-hydroxyisobutyrate
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
Sinorhizobium fredii
-
CoA + (S)-3-hydroxyisobutyrate
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
Sinorhizobium fredii NGR234
-
CoA + (S)-3-hydroxyisobutyrate
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
Sinorhizobium meliloti RmP798
-
CoA + (S)-3-hydroxyisobutyrate
-
-
ir
Organism
EC Number
Organism
UniProt
Commentary
Textmining
3.1.2.4
Sinorhizobium fredii
C3KM96
-
-
3.1.2.4
Sinorhizobium fredii NGR234
C3KM96
-
-
3.1.2.4
Sinorhizobium meliloti
-
-
-
3.1.2.4
Sinorhizobium meliloti RmP798
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
-
750422
Sinorhizobium meliloti
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
-
750422
Sinorhizobium fredii
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
-
750422
Sinorhizobium fredii NGR234
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
-
750422
Sinorhizobium meliloti RmP798
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
Synonyms
EC Number
Synonyms
Commentary
Organism
3.1.2.4
HIB-CoA hydrolase
-
Sinorhizobium fredii
3.1.2.4
HIB-CoA hydrolase
-
Sinorhizobium meliloti
3.1.2.4
NGR_b20860
-
Sinorhizobium fredii
3.1.2.4
Smb20752
-
Sinorhizobium meliloti
3.1.2.4
VutE
-
Sinorhizobium meliloti
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
Sinorhizobium meliloti
-
CoA + (S)-3-hydroxyisobutyrate
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
Sinorhizobium fredii
-
CoA + (S)-3-hydroxyisobutyrate
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
Sinorhizobium fredii NGR234
-
CoA + (S)-3-hydroxyisobutyrate
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
Sinorhizobium meliloti RmP798
-
CoA + (S)-3-hydroxyisobutyrate
-
-
ir
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
-
750422
Sinorhizobium meliloti
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
-
750422
Sinorhizobium fredii
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
-
750422
Sinorhizobium fredii NGR234
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
3.1.2.4
(S)-3-hydroxyisobutyryl-CoA + H2O
-
750422
Sinorhizobium meliloti RmP798
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
General Information
EC Number
General Information
Commentary
Organism
3.1.2.4
malfunction
enzyme deletion results in a loss of symbiotic N2-fixation
Sinorhizobium fredii
3.1.2.4
malfunction
enzyme deletion results in a loss of symbiotic N2-fixation
Sinorhizobium meliloti
3.1.2.4
metabolism
the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA
Sinorhizobium fredii
3.1.2.4
metabolism
the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA
Sinorhizobium meliloti
3.1.2.4
physiological function
the enzyme is required for efficient symbiotic nitrogen fixation
Sinorhizobium fredii
3.1.2.4
physiological function
the enzyme is required for efficient symbiotic nitrogen fixation
Sinorhizobium meliloti
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.2.4
malfunction
enzyme deletion results in a loss of symbiotic N2-fixation
Sinorhizobium fredii
3.1.2.4
malfunction
enzyme deletion results in a loss of symbiotic N2-fixation
Sinorhizobium meliloti
3.1.2.4
metabolism
the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA
Sinorhizobium fredii
3.1.2.4
metabolism
the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA
Sinorhizobium meliloti
3.1.2.4
physiological function
the enzyme is required for efficient symbiotic nitrogen fixation
Sinorhizobium fredii
3.1.2.4
physiological function
the enzyme is required for efficient symbiotic nitrogen fixation
Sinorhizobium meliloti