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Literature summary extracted from

  • Gokduman, K.
    Strategies targeting DNA topoisomerase I in cancer chemotherapy camptothecins, nanocarriers for camptothecins, organic non-camptothecin compounds and metal complexes (2016), Curr. Drug Targets, 17, 1928-1939 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.1 14-chloromethyl-12H-5,11adiazadibenzo[b,h]fluoren-11-one
-
 Homo sapiens
5.6.2.1 ARC-111
-
 Homo sapiens
5.6.2.1 camptothecin
-
 Homo sapiens
5.6.2.1 diaqua(2,2'-diamino-4,4'-bi-1,3-thiazole)oxosulfato-vanadium(IV) tetrahydrate
-
 Homo sapiens
5.6.2.1 edotecarin
-
 Homo sapiens
5.6.2.1 GENZ-644282
-
 Homo sapiens
5.6.2.1 gold(III) complex
-
 Homo sapiens
5.6.2.1 indimitecan
-
 Homo sapiens
5.6.2.1 indotecan
-
 Homo sapiens
5.6.2.1 irinotecan
-
 Homo sapiens
5.6.2.1 platinum(II) complex
-
 Homo sapiens
5.6.2.1 SN-38
-
 Homo sapiens
5.6.2.1 topotecan
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.2.1 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.1 786-O cell
-
 Homo sapiens
-
5.6.2.1 A-2780 cell
-
 Homo sapiens
-
5.6.2.1 breast cancer cell
-
 Homo sapiens
-
5.6.2.1 cervical cancer cell line
-
 Homo sapiens
-
5.6.2.1 GLC-4 cell
-
 Homo sapiens
-
5.6.2.1 H-460 cell
-
 Homo sapiens
-
5.6.2.1 HeLa cell
-
 Homo sapiens
-
5.6.2.1 kidney cancer cell
-
 Homo sapiens
-
5.6.2.1 lung cancer cell
-
 Homo sapiens
-
5.6.2.1 mammary epithelial cell
-
 Homo sapiens
-
5.6.2.1 MCF-10A cell
-
 Homo sapiens
-
5.6.2.1 MCF-7 cell
-
 Homo sapiens
-
5.6.2.1 ovarian carcinoma cell
-
 Homo sapiens
-
5.6.2.1 small cell lung cancer cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
5.6.2.1 DNA topoisomerase I
-
 Homo sapiens
5.6.2.1 Topo I
-
 Homo sapiens